结节病诊断后发展为特发性多中心Castleman病：1例报告及文献复习

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2025-01-01 DOI:10.1016/j.rmcr.2025.102188

Takumi Muramatsu , Masato Kono , Masaki Ishige , Takahiko Saito , Misato Higasa , Fumiya Nihashi , Yuya Aono , Mineo Katsumata , Hideki Miwa , Yoshihiro Miki , Taro Misaki , Yoshiro Otsuki , Dai Hashimoto , Noriyuki Enomoto , Takafumi Suda , Hidenori Nakamura

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引用次数: 0

摘要

一位72岁的女性在胸片上表现出异常阴影。20年前组织学诊断为结节病，8年前开始使用强的松龙。计算机断层扫描显示双肺小叶中心微结节和支气管维管束增厚伴多中心淋巴结病变；强的松龙减径期间出现多发肺结节性病变。实验室结果包括多克隆高γ -球蛋白血症和白细胞介素-6水平升高。手术肺活检显示明显的淋巴浆细胞浸润伴淋巴样聚集体。该患者人类疱疹病毒-8检测呈阴性，临床诊断为特发性多中心Castleman病。结节病与Castleman病共存的情况很少见；该病例通过额外的托珠单抗治疗得到改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Idiopathic multicentric Castleman disease developing after a diagnosis of sarcoidosis: A case report and literature review

A 72-year-old woman presented with an abnormal shadow on chest radiograph. She was histologically diagnosed with sarcoidosis 20 years previously, and prednisolone was initiated 8 years previously. Computed tomography revealed centrilobular micronodules and bronchovascular bundle thickening in both lungs with multicentric lymphadenopathies; multiple pulmonary nodular lesions appeared during prednisolone tapering. Laboratory findings included polyclonal hypergammaglobulinemia and elevated interleukin-6 levels. Surgical lung biopsy revealed marked lymphoplasmacytic infiltration with lymphoid aggregates. The patient tested negative for human herpesvirus-8 and clinically diagnosed with idiopathic multicentric Castleman disease. The coexistence of sarcoidosis and Castleman disease is rare; this case improved with additional tocilizumab treatment.

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