- Book学术

发布求助

文献互助智能选刊最新文献

AJO International Pub Date : 2025-02-23 DOI:10.1016/j.ajoint.2025.100108

Jeremy C.K. Tan , Yohei Hashimoto , Hamish Dunn , David Wechsler , Shweta Kaushik , Louis Arnould , Andrew White , Mitchell Lawlor , FGB registry

{"title":"Visual rehabilitation in subconjunctival MIGS versus trabeculectomy and tube shunt surgery","authors":"Jeremy C.K. Tan , Yohei Hashimoto , Hamish Dunn , David Wechsler , Shweta Kaushik , Louis Arnould , Andrew White , Mitchell Lawlor , FGB registry","doi":"10.1016/j.ajoint.2025.100108","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>To compare recovery of baseline visual acuity and persistent visual loss at 12-months in standalone subconjunctival minimally invasive glaucoma surgery (MIGS) vs trabeculectomy and tube shunt surgery in manifest and suspect glaucoma.</div></div><div><h3>Design</h3><div>Retrospective international multicenter study</div></div><div><h3>Methods</h3><div>Analysis of 974 eyes (Xen, 359; Trab, 455; Tube 160) of 847 subjects that underwent standalone Xen45 gel stent (Xen, 87 % ab-interno), trabeculectomy (Trab) or tube shunt (Tube) surgery with 12 months of follow-up. The primary outcome was time for visual acuity (VA) to return to within five letters of pre-operative baseline.</div></div><div><h3>Results</h3><div>The baseline glaucoma severity was significantly worse in the Tube group (mean deviation -10.4 vs -12.9 vs -14.4 dB in Xen vs Trab vs Tube, <em>P</em> < 0.001). The proportion of eyes that returned to within 5 letters of baseline VA at 12 months was 93.0 %, 88.6 % and 89.4 % respectively. Compared to the Trab group, the Xen had a significantly shorter median recovery time (9 vs 15 vs 15 days) and higher likelihood of return to baseline VA, including in a subcohort propensity score matched by baseline characteristics (OR 1.48, CI 1.18–1.87, <em>P</em> < 0.001). The Xen group however displayed lower surgical success than the Trab group. There was no significant difference in the rate of VA loss at 12 months (2.5 % vs 2.5 % vs 5 %, <em>P</em> = 0.21).</div></div><div><h3>Conclusions</h3><div>Subconjunctival minimally invasive glaucoma surgery displayed the fastest and a higher likelihood of return to baseline visual acuity compared to Trab and Tube surgery.</div></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"2 1","pages":"Article 100108"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AJO International","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950253525000115","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景比较独立结膜下微创青光眼手术（MIGS）与小梁切除术和导管分流术在显性和疑似青光眼患者中的基线视力恢复情况以及 12 个月时的持续视力下降情况。设计回顾性国际多中心研究方法分析了847名受试者的974只眼睛（Xen，359只；Trab，455只；Tube，160只），这些受试者接受了独立Xen45凝胶支架（Xen，87% ab-interno）、小梁切除术（Trab）或管道分流术（Tube）手术，随访12个月。主要结果是视力（VA）恢复到术前基线5个字母以内的时间。结果分流管组的基线青光眼严重程度明显更差（Xen vs Trab vs 分流管的平均偏差为-10.4 vs -12.9 vs -14.4 dB，P <0.001）。12 个月后，视力恢复到基线 5 个字母以内的眼睛比例分别为 93.0%、88.6% 和 89.4%。与 Trab 组相比，Xen 组的中位恢复时间明显更短（9 天 vs 15 天 vs 15 天），恢复到基线视力的可能性更高，包括在根据基线特征进行倾向评分匹配的子队列中（OR 1.48，CI 1.18-1.87, P <0.001）。不过，Xen 组的手术成功率低于 Trab 组。结论结膜下微创青光眼手术与Trab和Tube手术相比，恢复到基线视力的速度最快，可能性也更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Visual rehabilitation in subconjunctival MIGS versus trabeculectomy and tube shunt surgery

Background

To compare recovery of baseline visual acuity and persistent visual loss at 12-months in standalone subconjunctival minimally invasive glaucoma surgery (MIGS) vs trabeculectomy and tube shunt surgery in manifest and suspect glaucoma.

Design

Retrospective international multicenter study

Methods

Analysis of 974 eyes (Xen, 359; Trab, 455; Tube 160) of 847 subjects that underwent standalone Xen45 gel stent (Xen, 87 % ab-interno), trabeculectomy (Trab) or tube shunt (Tube) surgery with 12 months of follow-up. The primary outcome was time for visual acuity (VA) to return to within five letters of pre-operative baseline.

Results

The baseline glaucoma severity was significantly worse in the Tube group (mean deviation -10.4 vs -12.9 vs -14.4 dB in Xen vs Trab vs Tube, P < 0.001). The proportion of eyes that returned to within 5 letters of baseline VA at 12 months was 93.0 %, 88.6 % and 89.4 % respectively. Compared to the Trab group, the Xen had a significantly shorter median recovery time (9 vs 15 vs 15 days) and higher likelihood of return to baseline VA, including in a subcohort propensity score matched by baseline characteristics (OR 1.48, CI 1.18–1.87, P < 0.001). The Xen group however displayed lower surgical success than the Trab group. There was no significant difference in the rate of VA loss at 12 months (2.5 % vs 2.5 % vs 5 %, P = 0.21).

Conclusions

Subconjunctival minimally invasive glaucoma surgery displayed the fastest and a higher likelihood of return to baseline visual acuity compared to Trab and Tube surgery.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

AJO International

自引率

0.00%

发文量