脑室内出血外脑室引流患者中性粒细胞/淋巴细胞比值与临床预后的关系

IF 0.7 4区医学 Q4 NEUROSCIENCES

Neurocirugia Pub Date : 2025-03-01 DOI:10.1016/j.neucir.2024.10.007

Eylem Burcu Kahraman Özlü, Kaan Durmuş, Elçin Tuğce Mutlu, Ezgi Akar, Selin Tural, Arif Tarkan Çalışaneller

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引用次数: 0

摘要

背景：脑室出血（IVH）是神经外科实践中常见的病理，是所有颅内出血中临床预后最差的。脑室内的血液被认为通过引发炎症过程而使临床状况恶化。近年来，NLR值是一个常用的炎症参数，有很多文献报道高NLR值是预测炎症严重程度的重要标志。我们的研究旨在评估入院时NLR值对我院IVH致EVD患者临床转归的影响。材料与方法本研究对2019 - 2024年我院神经外科门诊36例IVH术后EVD患者的年龄、性别、入院格拉斯哥昏迷评分（GCS）、入院时NLR值及出院时临床状况进行了分析。结果本组36例患者中，女性16例，男性20例。所有病例的平均年龄为61.88岁，入院时平均GCS值为8.5。在我院化验室测得正常NLR范围为0.78-3.53，入院时NLR平均值为16.57。对病例的临床结局进行检查，重症监护随访后出院30例，出院6例，临床结局良好（GCS:15）。出院患者的NLR平均值为18.00，出院患者的NLR平均值为8.12。结论近年来，nlr被用于判断炎症的严重程度，并被报道为预测许多疾病临床结局的标志物。在我们的研究中，观察到所有病例入院时的NLR都很高，但以退场结束的病例的NLR明显高于非退场结束的病例。因此，我们认为NLR值可以作为预测IVH患者发生EVD的临床病程的参数。

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Relationship between NLR (Neutrophil/Lymphocyte ratio) value and clinical outcome in patients with external ventricular drainage due to intraventricular hemorrhage

Background

Intraventricular hemorrhages (IVH) are common pathologies in neurosurgery practice and are associated with the worst clinical outcome among all intracranial hemorrhages. Blood in the ventricles is thought to worsen the clinical condition by triggering inflammatory processes. In recent years, NLR value is a frequently used inflammatory parameter, and there are many publications reporting that a high NLR value is an important marker in predicting the severity of inflammation.

Our study aimed to evaluate the effect of NLR values at admission on the clinical outcome of patients undergoing EVD due to IVH in our clinic.

Material and methods

In our study, age and gender data, admission Glasgow Coma Scale (GCS), NLR value at the time of admission and clinical status at discharge of 36 patients, who underwent EVD following IVH in our hospital neurosurgery clinic between 2019 and 2024, were examined.

Results

Of the 36 cases in our study, 16 were female and 20 were male. For all cases, the mean age was 61.88, and the mean GCS values at admission were calculated as 8.5. In the laboratory of our hospital, the normal NLR range was determined as 0.78-3.53, and the mean NLR values at admission were evaluated as 16.57. When the clinical outcomes of the cases were examined, it was seen that 30 cases ended with exitus after intensive care follow-up, and 6 cases were discharged with good clinical outcomes (GCS:15). The mean NLR value was calculated as 18.00 for the patients who ended with exitus and 8.12 for the patients discharged with good clinical outcomes.

Conclusion

NLR, which has been used to determine the severity of inflammation in recent years, has been reported to be a marker that can predict clinical outcomes of many diseases. In our study, NLR was observed to be high at admission in all cases, but it was significantly higher in the cases ending with exitus than in the cases not ending with exitus. As a result, it is thought that NLR value is a parameter that can be used to predict the clinical course in IVH patients undergoing EVD.

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来源期刊

Neurocirugia 医学-神经科学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

60 days

期刊介绍： Neurocirugía is the official Journal of the Spanish Society of Neurosurgery (SENEC). It is published every 2 months (6 issues per year). Neurocirugía will consider for publication, original clinical and experimental scientific works associated with neurosurgery and other related neurological sciences. All manuscripts are submitted for review by experts in the field (peer review) and are carried out anonymously (double blind). The Journal accepts works written in Spanish or English.