优化溶胶-凝胶合成钛酸铝生物材料的可控制降解、生物活性和机械行为。

Shanmugapriya B, Shailajha S, Sakthi Muthulakshmi S
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引用次数: 0

摘要

摘要# xD;骨科应用需要平衡机械强度、生物相容性和可控降解的材料,特别是用于骨再生和承重目的。研究了Al2O3和TiO2的重量百分比(25:75,50:50和75:25)对溶胶-凝胶法制备的Al2TiO5生物材料性能的影响。结构和化学表征,包括XRD和FTIR,证实了相纯Al2TiO5的成功合成,突出了Al-O和Ti-O等官能团。在所测试的组合物中,50:50比例的组合物对金黄色葡萄球菌和大肠杆菌的抗菌效果最强,与商业抗生素相当,同时也促进羟基磷灰石(HAp)在模拟体液(SBF)中的沉积。此外,使用L929小鼠成纤维细胞系进行的细胞毒性评估显示,50:50的成分具有最低的毒性。所有的配方都显示出可控的降解,最大限度地减少pH波动,提高生物活性和生物相容性。Zeta电位分析表明,随着时间的推移,50:50的组成呈现出最大的负值,表明与SBF的表面相互作用强,有利于HAp成核。此外,所有配方的抗压强度(71-74 MPa)都足以承载应用。这些发现表明,优化50:50的重量比可以提高生物活性、机械稳定性和生物相容性,使其成为骨科和骨组织工程应用的有希望的候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimizing controlled degradation, bioactivity, and mechanical behavior in sol-gel synthesized aluminum titanate biomaterials.

Orthopaedic applications require materials that balance mechanical strength, biocompatibility, and controlled degradation, particularly for bone regeneration and load-bearing purposes. This study investigates the effects of varying weight percentages of Al2O3and TiO2(25:75, 50:50, and 75:25) on the characteristics of Al2TiO5biomaterials synthesized via the sol-gel method. Structural and chemical characterizations, including XRD and FTIR, confirmed the successful synthesis of phase-pure Al2TiO5, highlighting functional groups such as Al-O and Ti-O. Among the tested compositions, the 50:50 ratio exhibited the strongest antibacterial efficacy againstS. aureusandE. coli, comparable to a commercial antibiotic, while also promoting hydroxyapatite (HAp) deposition in simulated body fluid (SBF). Additionally, cytotoxicity assessments using the L929 murine fibroblast cell line revealed that the 50:50 composition had the lowest toxicity. All formulations demonstrated controlled degradation, minimizing pH fluctuations and enhancing bioactivation and biocompatibility. Zeta potential analysis indicated that the 50:50 composition exhibited the most negative values over time, suggesting strong surface interactions with SBF and a favorable environment for HAp nucleation. Furthermore, the compressive strength of all formulations (71-74 MPa) was sufficient for load-bearing applications. These findings suggest that optimizing the 50:50 weight ratio enhances bioactivity, mechanical stability, and biocompatibility, making it a promising candidate for orthopedic and bone tissue engineering applications.

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