Shanmugapriya B, Shailajha S, Sakthi Muthulakshmi S
{"title":"优化溶胶-凝胶合成钛酸铝生物材料的可控制降解、生物活性和机械行为。","authors":"Shanmugapriya B, Shailajha S, Sakthi Muthulakshmi S","doi":"10.1088/1748-605X/adbb46","DOIUrl":null,"url":null,"abstract":"<p><p>Orthopaedic applications require materials that balance mechanical strength, biocompatibility, and controlled degradation, particularly for bone regeneration and load-bearing purposes. This study investigates the effects of varying weight percentages of Al<sub>2</sub>O<sub>3</sub>and TiO<sub>2</sub>(25:75, 50:50, and 75:25) on the characteristics of Al<sub>2</sub>TiO<sub>5</sub>biomaterials synthesized via the sol-gel method. Structural and chemical characterizations, including XRD and FTIR, confirmed the successful synthesis of phase-pure Al<sub>2</sub>TiO<sub>5</sub>, highlighting functional groups such as Al-O and Ti-O. Among the tested compositions, the 50:50 ratio exhibited the strongest antibacterial efficacy against<i>S. aureus</i>and<i>E. coli</i>, comparable to a commercial antibiotic, while also promoting hydroxyapatite (HAp) deposition in simulated body fluid (SBF). Additionally, cytotoxicity assessments using the L929 murine fibroblast cell line revealed that the 50:50 composition had the lowest toxicity. All formulations demonstrated controlled degradation, minimizing pH fluctuations and enhancing bioactivation and biocompatibility. Zeta potential analysis indicated that the 50:50 composition exhibited the most negative values over time, suggesting strong surface interactions with SBF and a favorable environment for HAp nucleation. Furthermore, the compressive strength of all formulations (71-74 MPa) was sufficient for load-bearing applications. These findings suggest that optimizing the 50:50 weight ratio enhances bioactivity, mechanical stability, and biocompatibility, making it a promising candidate for orthopedic and bone tissue engineering applications.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimizing controlled degradation, bioactivity, and mechanical behavior in sol-gel synthesized aluminum titanate biomaterials.\",\"authors\":\"Shanmugapriya B, Shailajha S, Sakthi Muthulakshmi S\",\"doi\":\"10.1088/1748-605X/adbb46\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Orthopaedic applications require materials that balance mechanical strength, biocompatibility, and controlled degradation, particularly for bone regeneration and load-bearing purposes. This study investigates the effects of varying weight percentages of Al<sub>2</sub>O<sub>3</sub>and TiO<sub>2</sub>(25:75, 50:50, and 75:25) on the characteristics of Al<sub>2</sub>TiO<sub>5</sub>biomaterials synthesized via the sol-gel method. Structural and chemical characterizations, including XRD and FTIR, confirmed the successful synthesis of phase-pure Al<sub>2</sub>TiO<sub>5</sub>, highlighting functional groups such as Al-O and Ti-O. Among the tested compositions, the 50:50 ratio exhibited the strongest antibacterial efficacy against<i>S. aureus</i>and<i>E. coli</i>, comparable to a commercial antibiotic, while also promoting hydroxyapatite (HAp) deposition in simulated body fluid (SBF). Additionally, cytotoxicity assessments using the L929 murine fibroblast cell line revealed that the 50:50 composition had the lowest toxicity. All formulations demonstrated controlled degradation, minimizing pH fluctuations and enhancing bioactivation and biocompatibility. Zeta potential analysis indicated that the 50:50 composition exhibited the most negative values over time, suggesting strong surface interactions with SBF and a favorable environment for HAp nucleation. Furthermore, the compressive strength of all formulations (71-74 MPa) was sufficient for load-bearing applications. These findings suggest that optimizing the 50:50 weight ratio enhances bioactivity, mechanical stability, and biocompatibility, making it a promising candidate for orthopedic and bone tissue engineering applications.</p>\",\"PeriodicalId\":72389,\"journal\":{\"name\":\"Biomedical materials (Bristol, England)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical materials (Bristol, England)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1088/1748-605X/adbb46\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical materials (Bristol, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/1748-605X/adbb46","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Optimizing controlled degradation, bioactivity, and mechanical behavior in sol-gel synthesized aluminum titanate biomaterials.
Orthopaedic applications require materials that balance mechanical strength, biocompatibility, and controlled degradation, particularly for bone regeneration and load-bearing purposes. This study investigates the effects of varying weight percentages of Al2O3and TiO2(25:75, 50:50, and 75:25) on the characteristics of Al2TiO5biomaterials synthesized via the sol-gel method. Structural and chemical characterizations, including XRD and FTIR, confirmed the successful synthesis of phase-pure Al2TiO5, highlighting functional groups such as Al-O and Ti-O. Among the tested compositions, the 50:50 ratio exhibited the strongest antibacterial efficacy againstS. aureusandE. coli, comparable to a commercial antibiotic, while also promoting hydroxyapatite (HAp) deposition in simulated body fluid (SBF). Additionally, cytotoxicity assessments using the L929 murine fibroblast cell line revealed that the 50:50 composition had the lowest toxicity. All formulations demonstrated controlled degradation, minimizing pH fluctuations and enhancing bioactivation and biocompatibility. Zeta potential analysis indicated that the 50:50 composition exhibited the most negative values over time, suggesting strong surface interactions with SBF and a favorable environment for HAp nucleation. Furthermore, the compressive strength of all formulations (71-74 MPa) was sufficient for load-bearing applications. These findings suggest that optimizing the 50:50 weight ratio enhances bioactivity, mechanical stability, and biocompatibility, making it a promising candidate for orthopedic and bone tissue engineering applications.