重组DNA：解锁作物农业创新中未开发的微生物潜力。

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2025-03-01 DOI:10.1016/j.tibtech.2025.01.001

Aranksha Thakor, Trevor C Charles

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引用次数: 0

摘要

1975年举行的重组DNA Asilomar会议确立了重组DNA （rDNA）研究的指导方针，并为生物技术法规奠定了基础。虽然rDNA推动了制药和作物生物技术的重大进步，但利用rDNA开发的植物有益微生物的商业化却落后了。这种差异可能归因于繁琐的监管框架，这是由于人们认为rDNA产品会带来生物安全风险。为了充分发挥rDNA技术在应对全球挑战方面的潜力，必须对用于作物的rDNA衍生微生物产品进行监管改革，以减少对化肥和农药的依赖。简化这些障碍将使农业及其他领域的微生物解决方案产生更大的社会效益。

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Recombinant DNA: unlocking untapped microbial potential for innovation in crop agriculture.

The Asilomar Conference on Recombinant DNA, held in 1975, established guidelines for recombinant DNA (rDNA) research and laid the foundation for biotechnology regulations. While rDNA has driven significant advancements in pharmaceutical and crop biotechnology, the commercialization of plant-beneficial microbials developed using rDNA has lagged behind. This disparity may be attributed to a cumbersome regulatory framework shaped by the perception that rDNA products pose biosafety risks. To unlock the full potential of rDNA technology in addressing global challenges, regulatory reform for rDNA-derived microbial products for crop plants that reduce reliance on chemical fertilizers and pesticides is essential. Streamlining these barriers will enable greater societal benefits from microbial solutions in agriculture and beyond.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).