儿童阻塞性睡眠呼吸暂停高炎症状态的危险因素。

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Yanyu He, Xueyun Xu, Meng Lv, Wenjing Gu, Xinxing Zhang, Huie Zhu, Chuangli Hao, Yuqing Wang
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引用次数: 0

摘要

背景:阻塞性睡眠呼吸暂停(OSA)可诱发慢性全身性炎症,这可能是导致多种并发症的潜在机制。及时识别儿童OSA的高炎症状态(HIS)对于有效的临床诊断和治疗至关重要。本研究旨在评价hsCRP水平的影响因素,并进一步探讨儿童OSA患者HIS的相关危险因素。方法:在睡眠中心接受多导睡眠图(PSG)检查的3 ~ 15岁有打鼾症状的儿童被纳入本研究。所有的参与者都完成了一份全面的问卷调查、身体检查、鼻咽x光成像和血液检查。体格检查包括身高、体重测量和扁桃体肥大的视觉评估。结果:共有1171名儿童入组,其中562例诊断为OSA。利用ROC曲线生成的hsCRP阈值,299名和872名儿童分别表现为HIS和Low Inflammatory Status。与对照组相比,OSA组患者hsCRP水平明显升高。患有HIS的儿童OSA患者的BMI较高,超重和肥胖的比例也较高。Logistic回归分析显示HIS与BMI、平均阻塞性呼吸暂停时间独立正相关,与最小SpO2负相关。结论:儿童OSA患者HsCRP明显升高,BMI、平均阻塞性呼吸暂停时间和最低SpO2是导致HIS的独立因素。HsCRP可以作为一种有效的血液指标,能够识别与OSA相关的HIS个体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk factors of high inflammatory state in pediatric obstructive sleep apnea.

Background: Obstructive sleep apnea (OSA) may induce chronic systemic inflammation, which may serve as a potential mechanism contributing to multiple complications. The timely identification of high inflammatory status (HIS) in pediatric OSA is crucial for effective clinical diagnosis and management. This study aimed to evaluate influencing factors in hsCRP levels, and further investigated the risk factors associated with HIS in pediatric OSA patients.

Methods: Children aged 3 to 15 years who presented with snoring symptoms and underwent polysomnography (PSG) at the sleep center were included in this study. All participants completed a comprehensive questionnaire, a physical examination, nasopharyngeal X-ray imaging and a blood test. The physical examination included measurements of height, weight, and visual evaluation of tonsillar hypertrophy.

Results: A total of 1,171 children were enrolled, with 562 cases diagnosed with OSA. Utilizing threshold for hsCRP generated via ROC curve, 299 and 872 children exhibited HIS and Low Inflammatory Status, respectively. Compared to the control group, the hsCRP levels in the OSA group were significantly elevated. Pediatric OSA with HIS had higher BMI and a greater proportion of both overweight and obese. Logistic regression analysis demonstrated that HIS was independently positively correlated with BMI and mean time of obstructive apnea, and negatively associated with minimum SpO2.

Conclusions: HsCRP in pediatric OSA patients were notably elevated, whilst identifying BMI, mean time of obstructive apnea, and minimum SpO2 as independent factors leading to HIS. HsCRP may function as an effective blood index capable of identifying individuals exhibiting HIS linked to OSA.

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来源期刊
Sleep and Breathing
Sleep and Breathing 医学-呼吸系统
CiteScore
5.20
自引率
4.00%
发文量
222
审稿时长
3-8 weeks
期刊介绍: The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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