血清补体水平与侵袭性非霍奇金淋巴瘤诊断预后的相关性分析

Q4 Medicine

中国实验血液学杂志 Pub Date : 2025-02-01 DOI:10.19746/j.cnki.issn.1009-2137.2025.01.014

Bin-Bin Ding, Na-Na Li, Bai Dong, Zi-Jian Li

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引用次数: 0

摘要

目的：探讨侵袭性非霍奇金淋巴瘤（NHL）患者诊断时血清补体水平与预后的关系。方法：选取2017年2月至2023年3月兰州大学第一医院诊断的102例侵袭性非霍奇金淋巴瘤患者的临床资料，分析患者初诊时血清补体C3、C4水平与预后的相关性。通过受试者工作特征（ROC）曲线计算Jorden指数得出C3和C4的最佳分界点，将102例患者分为低C3组（C3< 1.07）和高C3组（C3≥1.07）、低C4组（C4< 0.255）和高C4组（C4≥0.255）。分析血清C3、C4水平对患者预后的影响。结果：ROC曲线分析显示，C3、C4预测侵袭性NHL患者预后的曲线下面积（AUC）分别为0.634 （95%CI:0.525 ~ 0.743;P =0.025）、0.651 （95%CI:0.541 ~ 0.761;P =0.012）。C3和C4的最佳分界点分别为1.07和0.255。K-M生存分析显示，C3和C4水平高的组无进展生存期（PFS）较短(P =0.0079；P =0.0092)和总生存期（OS） (P =0.021；P = 0.021)。多因素Cox分析显示，血清补体C3水平高（HR=2.37, 95%CI: 1.07 ~ 5.24, P =0.034）、年龄≥60岁（HR=2.34, 95%CI: 1.11 ~ 4.95, P =0.025）是侵袭性NHL患者PFS的独立危险因素。高补体C3水平（HR=2.37, 95%CI: 1.09-5.13, P =0.029）和诊断时年龄≥60岁（HR=2.40, 95%CI: 1.13-5.13, P =0.024）是侵袭性NHL患者发生OS的独立危险因素。结论：诊断时血清补体C3水平是影响侵袭性NHL患者预后的因素之一。

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[Correlation Analysis of Serum Complement Level and Prognosis in Diagnosis of Aggressive Non-Hodgkin Lymphoma].

Objective: To explore the relationship between serum complement levels at diagnosis and prognosis in patients with aggressive non-Hodgkin lymphoma(NHL).

Methods: The clinical data of 102 patients with aggressive non-Hodgkin lymphoma diagnosed in the First Hospital of Lanzhou University from February 2017 to March 2023 were selected to analyze the correlation between serum complement C3 and C4 levels and prognosis of patients with aggressive NHL at the time of initial diagnosis. The optimal cut-off point of C3 and C4 were obtained by calculating the Jorden index through the receiver operating characteristic（ROC） curve, and 102 patients were divided into low C3 group (C3< 1.07) and high C3 group (C3≥1.07), low C4 group (C4< 0.255) and high C4 group (C4≥0.255). The effects of serum C3 and C4 levels on the prognosis of these patients were analyzed.

Results: ROC curve analysis showed that the area under the curve (AUC) of C3 and C4 in predicting the prognosis of aggressive NHL patients was 0.634 (95%CI ：0.525-0.743；P =0.025) and 0.651 (95%CI ：0.541-0.761；P =0.012), respectively. The optimal cut-off points for C3 and C4 were 1.07 and 0.255, respectively. K-M survival analysis showed that groups with high C3 and C4 levels had shorter progression-free survival (PFS) (P =0.0079; P =0.0092) and overall survival (OS) (P =0.021; P =0.021). Multivariate Cox analysis showed that high level serum complement C3 (HR=2.37, 95%CI : 1.07-5.24, P =0.034) and age ≥60 years (HR=2.34, 95%CI : 1.11-4.95, P =0.025) were independent risk factors for PFS in patients with aggressive NHL. High level complement C3 (HR=2.37, 95%CI : 1.09-5.13, P =0.029) and age ≥60 years at diagnosis (HR=2.40, 95%CI : 1.13-5.13, P =0.024) were independent risk factors for OS in patients with aggressive NHL.