{"title":"[鼻外NK/ t细胞淋巴瘤患者临床特点及预后分析：淮海淋巴瘤工作组多中心回顾性研究]。","authors":"Hui-Rong Shan, Qing Zhang, Ling Wang, Yu-Ye Shi, Yu-Qing Miao, Tai-Gang Zhu, Jing-Jing Ye, Xu-Dong Zhang, Liang Wang, Zi-Yuan Shen, Wei Sang","doi":"10.19746/j.cnki.issn.1009-2137.2025.01.013","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical characteristics and prognostic factors of patients with extranasal NK/T-cell lymphoma (NKTCL).</p><p><strong>Methods: </strong>The clinical data of 138 patients with NKTCL diagnosed in 10 medical centers of Huaihai Lymphoma Working Group from June 2015 to April 2021 were collected and analyzed retrospectively. The differences in clinicopathological characteristics of patients with different involvement and efficacy of pegaspargase regimen were compared, as well as perform survival analysis.</p><p><strong>Results: </strong>A total of 138 extranasal NKTCL patients were included, with a median age of 46 years, and the ratio of males to females was approximately 2∶1. There were 39 patients with gastrointestinal involvement, 32 patients with oropharyngeal involvement, 17 patients with skin involvement, 11 patients with lymph node involvement, 11 patients with orbital involvement, and 28 patients with other parts involvement. Patients with skin involvement had a higher proportion of advanced disease and a lower proportion of CD56 positive rate compared to those with oropharyngeal involvement. Among the patients with gastrointestinal involvement, the survival rate of patients who received pegaspargase regimen was significantly higher than those who were treated without pegaspargase (<i>P</i> < 0.01). Multivariate analysis showed that serum creatinine was an independent prognostic factor for patients with skin involvement ( <i>HR</i> =1.027, 95%<i>CI</i> : 1.001-1.054, <i>P</i> =0.040), ECOG PS and EBV DNA were independent prognostic factors for patients with gastrointestinal involvement ( <i>HR</i> =2.635, 95%<i>CI</i> : 1.096-6.338, <i>P</i> =0.030; <i>HR</i> =4.772, 95% <i>CI</i> : 1.092-20.854, <i>P</i> =0.038), and ECOG PS and CA stage were independent prognostic factors for patients with oropharyngeal involvement ( <i>HR</i> =13.875, 95%<i>CI</i> : 2.517-76.496, <i>P</i> =0.002; <i>HR</i> =20.261, 95%<i>CI</i> : 2.466-166.470, <i>P</i> =0.005).</p><p><strong>Conclusion: </strong>The clinicopathological characteristics of extranasal NKTCL patients with different sites of involvement are vary, and effective individualized treatment need to be further explored.</p>","PeriodicalId":35777,"journal":{"name":"中国实验血液学杂志","volume":"33 1","pages":"93-100"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Clinical Characteristics and Prognosis Analysis of Patients with Extranasal NK/T-Cell Lymphoma: A Multicenter Retrospective Study of Huaihai Lymphoma Working Group].\",\"authors\":\"Hui-Rong Shan, Qing Zhang, Ling Wang, Yu-Ye Shi, Yu-Qing Miao, Tai-Gang Zhu, Jing-Jing Ye, Xu-Dong Zhang, Liang Wang, Zi-Yuan Shen, Wei Sang\",\"doi\":\"10.19746/j.cnki.issn.1009-2137.2025.01.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the clinical characteristics and prognostic factors of patients with extranasal NK/T-cell lymphoma (NKTCL).</p><p><strong>Methods: </strong>The clinical data of 138 patients with NKTCL diagnosed in 10 medical centers of Huaihai Lymphoma Working Group from June 2015 to April 2021 were collected and analyzed retrospectively. The differences in clinicopathological characteristics of patients with different involvement and efficacy of pegaspargase regimen were compared, as well as perform survival analysis.</p><p><strong>Results: </strong>A total of 138 extranasal NKTCL patients were included, with a median age of 46 years, and the ratio of males to females was approximately 2∶1. There were 39 patients with gastrointestinal involvement, 32 patients with oropharyngeal involvement, 17 patients with skin involvement, 11 patients with lymph node involvement, 11 patients with orbital involvement, and 28 patients with other parts involvement. Patients with skin involvement had a higher proportion of advanced disease and a lower proportion of CD56 positive rate compared to those with oropharyngeal involvement. Among the patients with gastrointestinal involvement, the survival rate of patients who received pegaspargase regimen was significantly higher than those who were treated without pegaspargase (<i>P</i> < 0.01). Multivariate analysis showed that serum creatinine was an independent prognostic factor for patients with skin involvement ( <i>HR</i> =1.027, 95%<i>CI</i> : 1.001-1.054, <i>P</i> =0.040), ECOG PS and EBV DNA were independent prognostic factors for patients with gastrointestinal involvement ( <i>HR</i> =2.635, 95%<i>CI</i> : 1.096-6.338, <i>P</i> =0.030; <i>HR</i> =4.772, 95% <i>CI</i> : 1.092-20.854, <i>P</i> =0.038), and ECOG PS and CA stage were independent prognostic factors for patients with oropharyngeal involvement ( <i>HR</i> =13.875, 95%<i>CI</i> : 2.517-76.496, <i>P</i> =0.002; <i>HR</i> =20.261, 95%<i>CI</i> : 2.466-166.470, <i>P</i> =0.005).</p><p><strong>Conclusion: </strong>The clinicopathological characteristics of extranasal NKTCL patients with different sites of involvement are vary, and effective individualized treatment need to be further explored.</p>\",\"PeriodicalId\":35777,\"journal\":{\"name\":\"中国实验血液学杂志\",\"volume\":\"33 1\",\"pages\":\"93-100\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国实验血液学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.19746/j.cnki.issn.1009-2137.2025.01.013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国实验血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.19746/j.cnki.issn.1009-2137.2025.01.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨鼻外NK/ t细胞淋巴瘤（NKTCL）的临床特点及影响预后的因素。方法：回顾性分析淮海淋巴瘤工作组10个医疗中心2015年6月至2021年4月诊断的138例NKTCL患者的临床资料。比较pegaspargase方案不同受病患者的临床病理特征及疗效差异，并进行生存分析。结果：共纳入鼻外NKTCL患者138例，中位年龄46岁，男女比例约为2∶1。胃肠道受累39例，口咽受累32例，皮肤受累17例，淋巴结受累11例，眼眶受累11例，其他部位受累28例。与口咽部受累患者相比，皮肤受累患者的晚期疾病比例更高，CD56阳性率比例更低。在累及胃肠道的患者中，接受pegaspargase治疗的患者生存率显著高于未接受pegaspargase治疗的患者（P < 0.01）。多因素分析显示，血清肌酐是皮肤受累患者的独立预后因素（HR =1.027, 95%CI: 1.001 ~ 1.054, P =0.040）， ECOG PS和EBV DNA是胃肠道受累患者的独立预后因素(HR =2.635, 95%CI: 1.096 ~ 6.338, P =0.030；HR =4.772, 95%CI: 1.092 ~ 20.854, P =0.038)， ECOG PS和CA分期是口咽受累患者的独立预后因素(HR =13.875, 95%CI: 2.517 ~ 76.496, P =0.002；Hr =20.261, 95%ci: 2.466 ~ 166.470, p =0.005)。结论：不同受损伤部位的鼻外NKTCL患者临床病理特点不同，需要进一步探索有效的个体化治疗。
[Clinical Characteristics and Prognosis Analysis of Patients with Extranasal NK/T-Cell Lymphoma: A Multicenter Retrospective Study of Huaihai Lymphoma Working Group].
Objective: To explore the clinical characteristics and prognostic factors of patients with extranasal NK/T-cell lymphoma (NKTCL).
Methods: The clinical data of 138 patients with NKTCL diagnosed in 10 medical centers of Huaihai Lymphoma Working Group from June 2015 to April 2021 were collected and analyzed retrospectively. The differences in clinicopathological characteristics of patients with different involvement and efficacy of pegaspargase regimen were compared, as well as perform survival analysis.
Results: A total of 138 extranasal NKTCL patients were included, with a median age of 46 years, and the ratio of males to females was approximately 2∶1. There were 39 patients with gastrointestinal involvement, 32 patients with oropharyngeal involvement, 17 patients with skin involvement, 11 patients with lymph node involvement, 11 patients with orbital involvement, and 28 patients with other parts involvement. Patients with skin involvement had a higher proportion of advanced disease and a lower proportion of CD56 positive rate compared to those with oropharyngeal involvement. Among the patients with gastrointestinal involvement, the survival rate of patients who received pegaspargase regimen was significantly higher than those who were treated without pegaspargase (P < 0.01). Multivariate analysis showed that serum creatinine was an independent prognostic factor for patients with skin involvement ( HR =1.027, 95%CI : 1.001-1.054, P =0.040), ECOG PS and EBV DNA were independent prognostic factors for patients with gastrointestinal involvement ( HR =2.635, 95%CI : 1.096-6.338, P =0.030; HR =4.772, 95% CI : 1.092-20.854, P =0.038), and ECOG PS and CA stage were independent prognostic factors for patients with oropharyngeal involvement ( HR =13.875, 95%CI : 2.517-76.496, P =0.002; HR =20.261, 95%CI : 2.466-166.470, P =0.005).
Conclusion: The clinicopathological characteristics of extranasal NKTCL patients with different sites of involvement are vary, and effective individualized treatment need to be further explored.
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