{"title":"血清神经丝轻链作为不宁腿综合征的潜在生物标志物：一项横断面研究。","authors":"Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran","doi":"10.1080/01616412.2025.2472836","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Neurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).</p><p><strong>Method: </strong>This cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.</p><p><strong>Result: </strong>No significant differences in NfL levels were observed between RLS patients and controls (<i>p</i> > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>These findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are needed to evaluate its role in RLS.</p>","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"284-289"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study.\",\"authors\":\"Aysu Yetis, Asuman Celikbilek, Bilal Ilanbey, Naime Meric Konar, Selcen Duran\",\"doi\":\"10.1080/01616412.2025.2472836\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Neurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).</p><p><strong>Method: </strong>This cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.</p><p><strong>Result: </strong>No significant differences in NfL levels were observed between RLS patients and controls (<i>p</i> > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>These findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are needed to evaluate its role in RLS.</p>\",\"PeriodicalId\":19131,\"journal\":{\"name\":\"Neurological Research\",\"volume\":\" \",\"pages\":\"284-289\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurological Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/01616412.2025.2472836\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01616412.2025.2472836","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/28 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study.
Objective: Neurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).
Method: This cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.
Result: No significant differences in NfL levels were observed between RLS patients and controls (p > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (p > 0.05).
Conclusion: These findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are needed to evaluate its role in RLS.
期刊介绍：
Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields.
The scope of the journal includes:
•Stem cell applications
•Molecular neuroscience
•Neuropharmacology
•Neuroradiology
•Neurochemistry
•Biomathematical models
•Endovascular neurosurgery
•Innovation in neurosurgery.
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