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IF 2 4区医学 Q3 GENETICS & HEREDITY

Lifestyle Genomics Pub Date : 2025-02-27 DOI:10.1159/000544832

Sai Sravani Vennam, Valentina Talevi, Geethika Venkataraman, Rayyan Ahmed Syed, Xinruo Zhang, Baba B Mass, Venkata Saroja Voruganti

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引用次数: 0

摘要

33 引言：过量摄入果糖与血脂异常、胰岛素、34 耐药性、高尿酸血症、炎症和肥胖的风险增加有关。在这项人体研究中，我们调查了摄入果糖后血清 35 CRP 浓度是否会发生变化，以及基因变异和肥胖状况是否会影响这种变化：方法：在摄入果糖前和摄入果糖后的四个时间点 37 抽取血液（n=57）。测量血清 CRP 浓度，38 并对以前与血清 CRP 相关的 11 个单核苷酸多态性（SNPs）（rs1205、rs1417938、rs1470515、rs3093068、39 rs6588158、rs16842568、rs2259820、rs157581、rs2794521、rs3093062、rs17700633）进行基因分型，评估它们与 41 CRP 水平的关系：结果：在所有时间点上，白人参与者（n = 37）的平均 CRP 水平均高于黑人参与者（n = 20）。与非肥胖者（n = 32）相比，肥胖者（体重指数≥ 30 43 kg/m2）（n = 25）更年轻，在整个研究期间的平均 CRP 水平也更高。所有 SNP 均处于哈代-温伯格平衡状态，其 45 效应等位基因频率介于 11% 与 96% 之间。基线 CRP 与 CRP 46 SNPs rs1417938 和 rs2794521 相关（p 结论：血清 CRP 的变化与 CRP 46 SNPs rs1417938 和 rs2794521 相关：血清 CRP 的变化与肥胖状况 51 或摄入果糖后的 SNPs 有关。需要更大规模的研究52 来确认和验证这些关联。53 54.

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A Pilot Study to Evaluate the Role of Obesity and Genetic Variants in Serum C-Reactive Protein Response to an Acute Fructose Load.

33 Introduction: Excess fructose intake has been linked to increased risk for dyslipidemia, insulin, 34 resistance, hyperuricemia, inflammation, and obesity. In this human study, we investigated if serum 35 CRP concentrations change after fructose consumption, and whether genetic variants and 36 obesity status influences this change.

Methods: Blood was drawn before and at four time points 37 after administration of a fructose load (n=57). Serum concentrations of CRP were measured, 38 and 11 single nucleotides polymorphisms (SNPs) (rs1205, rs1417938, rs1470515, rs3093068, 39 rs6588158, rs16842568, rs2259820, rs157581, rs2794521, rs3093062, rs17700633), 40 previously associated with serum CRP were genotyped and assessed for their association with 41 CRP levels.

Results: Participants identifying as White (n = 37) had higher mean CRP levels across 42 all time points compared to those identifying as Black (n = 20). Participants with obesity (BMI ≥ 30 43 kg/m2) (n = 25) were younger and had higher mean CRP levels throughout the study period 44 compared to those without (n = 32). All SNPs were in Hardy-Weinberg Equilibrium and their 45 effect allele frequencies ranged between 11and 96%. Baseline CRP was associated with CRP 46 SNPs rs1417938 and rs2794521 (p <0.005), with rs2794521 also associated with CRP response to 47 fructose challenge (p < 0.005). The variability in responses to fructose and genetic associations 48 were mainly observed in individuals without obesity. Obesity status was associated with early 49 changes in CRP (0-30 min and 30-60min) whereas CRP SNPs were associated with later changes 50 (60-120min and 120-180 min).

Conclusion: Changes in serum CRP were associated with obesity 51 status or SNPs based on the time elapsed since fructose ingestion. Larger studies are needed to 52 confirm and validate these associations. 53 54.

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来源期刊

Lifestyle Genomics Agricultural and Biological Sciences-Food Science

CiteScore

4.00

自引率

7.70%

发文量

审稿时长

28 weeks

期刊介绍： Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.