IF 1.9 4区 医学 Q3 INFECTIOUS DISEASES
Masayuki Maeda , Satoshi Kakiuchi , Yuichi Muraki
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引用次数: 0

摘要

将抗菌药物使用指标的自动收集纳入国家监测系统对抗菌药物管理评估至关重要。抗生素谱覆盖天数(DASC)是评估降级策略的量化指标。目前面临的一个主要挑战是 DASC 尚未纳入国家监测系统,部分原因是最初制定的抗生素频谱覆盖率(ASC)评分中遗漏了日本常用的抗生素。本研究旨在为日本批准的抗生素建立 ASC 评分,并生成支持将其纳入国家监测系统的数据。本研究确定了日本批准使用的抗生素中尚未在之前的研究中获得 ASC 评分的抗生素。采用与最初研究相同的方法,针对 16 个生物类别评估了这些抗生素的抗菌活性。我们分析了日本批准的抗生素的准入、观察、储备(AWaRe)分类与 ASC 评分之间的相关性。ASC 评分范围为 3-16,中位数为 7。AWaRe 分级与 ASC 评分略有相关(Spearman's ρ = 0.234)。我们的研究结果凸显了采用不同的抗菌药物使用指标来全面评估抗菌药物管理的重要性。本研究的结果将有助于相关人员将 ASC 评分纳入国家监测系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assignments of antibiotic spectrum coverage scores of antibiotic agents approved in Japan: Utilization of the days of antibiotic spectrum coverage
Integrating the automated collection of antimicrobial use metrics into national surveillance systems is vital for antimicrobial stewardship evaluation. The days of antibiotic spectrum coverage (DASC) serves as a quantitative metric for assessing de-escalation strategies. A major challenge is that DASC has not yet been integrated into the national surveillance system, partly owing to the omission of commonly used antibiotics in Japan in the initially developed antibiotic spectrum coverage (ASC) scores. This study aimed to establish ASC scores for antibiotics approved in Japan and generate data supporting their integration into the national surveillance system. Antibiotics approved in Japan that had not been assigned ASC scores in the prior study were identified. Their antimicrobial activity was assessed against 16 organism categories using the same methodology as the original study. We analyzed the correlation between the Access, Watch, Reserve (AWaRe) classification and ASC scores for antibiotics approved in Japan. The ASC scores had a range of 3–16, with a median of seven. The AWaRe classification was slightly correlated with ASC scores (Spearman's ρ = 0.234). Our findings highlight the significance of employing diverse antimicrobial use metrics for comprehensively evaluating antimicrobial stewardship. The results of this study will support stakeholders in implementing ASC scores into the national surveillance system.
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来源期刊
Journal of Infection and Chemotherapy
Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
4.10
自引率
4.50%
发文量
303
审稿时长
47 days
期刊介绍: The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.
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