在生物医学研究中重新审视鸡胚胎模型的科学案例。

IF 2.5 3区生物学 Q2 DEVELOPMENTAL BIOLOGY

Developmental biology Pub Date : 2025-02-25 DOI:10.1016/j.ydbio.2025.02.013

Mike J. McGrew , Tana Holmes , Megan G. Davey

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引用次数: 0

摘要

可获得的受精卵以及禽类胚胎的可获得性和快速发育，已被用于生物医学科学研究，以取得基础发现，包括所有脊椎动物共同的发育过程、致畸学的进展、对肿瘤生长和转移的了解、血管生成、癌症药物评估和疫苗开发，以及对禽类特异性生物学的了解。然而，最近在鸡转基因、基因组工程和鸡代宿主技术方面的创新仅在这些研究领域的少数领域得到应用，特别是在发育生物学、鸟类性别决定和免疫学的一些领域。为了理解为什么其他生物医学领域没有采用现代鸡转基因工具，我们调查了2017-2023年间英国根据《1986年动物（科学程序）法》批准的项目的非技术摘要，以评估鸡胚胎何时以及如何用于研究，以及它们是否被视为其他物种的替代模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A scientific case for revisiting the embryonic chicken model in biomedical research

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A scientific case for revisiting the embryonic chicken model in biomedical research

The availability of fertilised chicken eggs and the accessibility and rapid development of the avian embryo, have been utilised in biomedical scientific research to make fundamental discoveries including of developmental processes that are common to all vertebrates, advances in teratology, the understanding of tumour growth and metastasis, angiogenesis, cancer drug assessment and vaccine development as well as advances in understanding avian specific biology. However, recent innovations in chicken transgenesis, genome engineering and surrogate host technology in chickens have only been utilised in a few of these fields of research, specifically some areas of developmental biology, avian sex determination and immunology. To understand why other biomedical fields have not adopted modern chicken transgenic tools, we investigated the non-technical summaries of projects granted in the UK under the Animals (Scientific Procedures) Act 1986 between 2017 and 2023 to assess when and how chicken embryos are used in research, and if they were considered as a Replacement model for other species.

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来源期刊

Developmental biology 生物-发育生物学

CiteScore

5.30

自引率

3.70%

发文量

182

审稿时长

1.5 months

期刊介绍： Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals.