放射性药物在癌症治疗中的应用进展及未来发展方向。

IF 2.9 3区 医学 Q2 ONCOLOGY
Expert Review of Anticancer Therapy Pub Date : 2025-04-01 Epub Date: 2025-03-03 DOI:10.1080/14737140.2025.2472859
Sikander Ailawadhi, Deanna Pafundi, Jennifer Peterson
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引用次数: 0

摘要

靶向放射性药物治疗(RPTs)已成为一种有前途的方法来精确治疗各种癌症。放射性药物直接向癌细胞提供电离辐射,同时不影响周围的健康组织,与传统的外部束放射治疗(即光子和电子)相比,它具有更高的疗效和更低的毒性。涵盖领域:在当前个性化癌症治疗的时代,需要更好地了解针对临床状况和特定患者护理的rpt的适当选择。几种可用的RPT药物具有各自的临床适用性,以及该领域正在快速进行的研究,现在使RPT能够使自己成为个性化医疗的重点。本文综述了近年来RPT的研究进展,包括核素选择与开发、分子靶向策略、放射性药物开发和临床应用。专家意见:我们讨论了未来发展的基本原则、挑战和机遇。此外,我们还探讨了该领域的新兴技术和未来方向,强调了对个性化癌症治疗的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances and future directions in radiopharmaceutical delivery for cancer treatment.

Introduction: Targeted radiopharmaceutical therapies (RPTs) have emerged as a promising approach for the precise treatment of various cancers. Delivering ionizing radiation directly to cancer cells while sparing surrounding healthy tissue, radiopharmaceuticals offer enhanced efficacy and reduced toxicity compared to conventional external beam radiation therapy (i.e. photons and electrons).

Areas covered: In the current era of personalized cancer care, the appropriate choice of RPTs for a clinical condition and the specific patient's care needs to be better understood. Several available RPT agents with their respective clinical applicability along with rapidly ongoing research in this field have now given RPTs the ability to lend themselves to a personalized medicine focus. This review provides an overview of recent advancements in RPT, including nuclide selection and development, molecular targeting strategies, radiopharmaceutical development, and clinical applications.

Expert opinion: We discuss the underlying principles, challenges, and opportunities for future development. Furthermore, we explore emerging technologies and future directions in the field, highlighting the potential impact on personalized cancer care.

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来源期刊
CiteScore
5.10
自引率
3.00%
发文量
100
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.
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