{"title":"XPhos Pd G3催化Buchwald偶联合成1,2,4-恶二唑衍生物","authors":"Deepak Kumar, Suryakanta Dalai, Mukesh Jangir","doi":"10.1007/s10562-025-04946-5","DOIUrl":null,"url":null,"abstract":"<div><p>The synthesis of oxadiazole compounds is of significant interest due to their diverse applications in pharmaceuticals and materials science. This study investigates the use of XPhos Pd G3 as a catalyst in the Buchwald coupling reaction for the efficient synthesis of 1,2,4-oxadiazole derivatives. The primary objective was to develop a reliable and scalable method to produce these compounds with high yield and purity. Our results demonstrate that the XPhos Pd G3 catalyst significantly enhances the Buchwald coupling process, achieving yields of up to 81% under optimized conditions. The synthesized 1,2,4-oxadiazoles exhibited excellent structural integrity and were characterized using NMR and mass spectrometry. These findings underscore the potential of XPhos Pd G3 as a powerful catalyst in organic synthesis, paving the way for further development of oxadiazole-based compounds with potential applications in drug development and materials science. Future research will focus on exploring the scope of this method across a broader range of substrates and applications.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":508,"journal":{"name":"Catalysis Letters","volume":"155 4","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of 1,2,4-Oxadiazole Derivatives via XPhos Pd G3 Catalyzed Buchwald Coupling\",\"authors\":\"Deepak Kumar, Suryakanta Dalai, Mukesh Jangir\",\"doi\":\"10.1007/s10562-025-04946-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The synthesis of oxadiazole compounds is of significant interest due to their diverse applications in pharmaceuticals and materials science. This study investigates the use of XPhos Pd G3 as a catalyst in the Buchwald coupling reaction for the efficient synthesis of 1,2,4-oxadiazole derivatives. The primary objective was to develop a reliable and scalable method to produce these compounds with high yield and purity. Our results demonstrate that the XPhos Pd G3 catalyst significantly enhances the Buchwald coupling process, achieving yields of up to 81% under optimized conditions. The synthesized 1,2,4-oxadiazoles exhibited excellent structural integrity and were characterized using NMR and mass spectrometry. These findings underscore the potential of XPhos Pd G3 as a powerful catalyst in organic synthesis, paving the way for further development of oxadiazole-based compounds with potential applications in drug development and materials science. Future research will focus on exploring the scope of this method across a broader range of substrates and applications.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":508,\"journal\":{\"name\":\"Catalysis Letters\",\"volume\":\"155 4\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Catalysis Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10562-025-04946-5\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Catalysis Letters","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10562-025-04946-5","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Synthesis of 1,2,4-Oxadiazole Derivatives via XPhos Pd G3 Catalyzed Buchwald Coupling
The synthesis of oxadiazole compounds is of significant interest due to their diverse applications in pharmaceuticals and materials science. This study investigates the use of XPhos Pd G3 as a catalyst in the Buchwald coupling reaction for the efficient synthesis of 1,2,4-oxadiazole derivatives. The primary objective was to develop a reliable and scalable method to produce these compounds with high yield and purity. Our results demonstrate that the XPhos Pd G3 catalyst significantly enhances the Buchwald coupling process, achieving yields of up to 81% under optimized conditions. The synthesized 1,2,4-oxadiazoles exhibited excellent structural integrity and were characterized using NMR and mass spectrometry. These findings underscore the potential of XPhos Pd G3 as a powerful catalyst in organic synthesis, paving the way for further development of oxadiazole-based compounds with potential applications in drug development and materials science. Future research will focus on exploring the scope of this method across a broader range of substrates and applications.
期刊介绍：
Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis.
The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.
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