心血管疾病中的氧化应激:机制和探索先进的治疗方法。

Dushyant -, Balram -, Gurvirender Singh, Nitish Kumar, Smita Narwal, Ashwani K Dhingra
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引用次数: 0

摘要

氧化应激作为影响心血管疾病(cvd)发生和发展的一个因素的认识正在增长。通过在细胞内的不同区域产生活性氧(ROS),包括线粒体和烟酰胺腺嘌呤二核苷酸磷酸氢(NADPH)氧化酶,它们最终通过脂质、蛋白质和DNA的氧化造成损害。ROS预示着炎症反应和内皮功能障碍的开始,这是血管阻塞和血管功能下降所必需的。氧化应激在心血管疾病的发展中起着重要作用,这一事实引起了人们对旨在纠正氧化还原失衡的新疗法的更多关注。因此,天然多酚和抗氧化剂,如维生素C或E,已经显示出它们在降低活性氧水平和防止氧化应激造成的损害方面的功效。任何试图治愈心血管疾病的人都应该专注于提高抗氧化治疗的安全性和有效性,并确定哪些患者将从中受益最多。本文不仅讨论了氧化应激在高血压、高胆固醇血症和缺血性心脏病等心血管疾病中的作用,而且还讨论了先进的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative Stress in Cardiovascular Diseases: Mechanisms and Exploring Advanced Therapies.

The recognition of oxidative stress as a factor influencing the development and progression of cardiovascular diseases (CVDs) is growing. By producing such reactive oxygen species (ROS) in diverse areas within cells, including mitochondria and Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NADPH)-oxidases, they end up causing damage through the oxidation of lipids, proteins, and DNA. ROS indicates the beginning of inflammatory responses and endothelial dysfunction, which are necessary to produce obstructions in blood vessels and decreased blood vessel function. The fact that oxidative stress plays a significant role in CVD development draws more attention to the need for novel therapies that aim to correct redox imbalances. Therefore, natural polyphenols and antioxidants like vitamin C or E have shown their efficacy in lowering levels of ROS and protecting against the damage caused by oxidative stress. Anyone attempting to cure CVDs should focus on improving the safety and efficacy of antioxidant treatments and identifying which patients will benefit from them the most. This paper discusses not only advanced treatments but also the role played by oxidative stress in such CVD as high blood pressure, hypercholesterolemia, and ischemic heart disease.

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