卒中和冠心病患者血压变异性的剂量反应。

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reviews Pub Date : 2025-02-26 DOI:10.2174/0115734021346604250214071418

Woro Riyadina, Sulistyowati Tuminah, Lely Indrawati, Nikson Sitorus, Alfons M Letelay, Tri Wurisastuti, Alifa Syamantha Putri, Ika Suswanti, Yuda Turana

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引用次数: 0

摘要

背景：血压变异性（BPV）是血管事件和触发靶器官损伤的潜在预测因子。目的：本研究旨在通过印度尼西亚茂物队列研究确定脑卒中和冠心病（CHD）患者的BPV。方法：通过6年的监测，对来自茂物非传染性疾病危险因素队列研究的1649名年龄≥31岁的受访者进行前瞻性队列研究。因变量为血管事件（中风或冠心病），即6年监测期间（2011 - 2017年和2012-2018年）出现的新病例（事件）。结果：在6年的监测中，血管事件发生率为12.4%。收缩期和舒张期BPV在血管事件、中风和冠心病中的剂量反应显示，与第1分位数（Q1）相比，风险增加（Q2、Q3和Q4分位数）。在6年的观察期间，在控制年龄、高血压状态和血脂后，收缩期BPV≥12,10 mmHg和舒张期BPV≥7,31 mmHg的血管事件风险分别为2.3和1.7（95%置信区间（CI））。结论：BPV是血管事件、脑卒中和冠心病的独立预测因子。公众和临床医生必须注意控制BPV作为血管事件、中风和冠心病的危险因素。

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The Dose-response of Blood Pressure Variability in Stroke and Coronary Heart Disease.

Background: Blood pressure variability (BPV) is a potential predictor of vascular events and triggers target organ damage.

Objective: This study aimed to determine the BPV in stroke and coronary heart disease (CHD) in the Bogor Cohort Study in Indonesia.

Methods: Over six years of monitoring, a prospective cohort study was conducted on 1649 respondents aged ≥ 31 years from the Bogor Non-communicable Diseases Risk Factors Cohort Study. The dependent variable was vascular events (stroke or CHD), which were new cases (incidents) that appeared during the 6-year monitoring period (2011 - 2017 and 2012-2018).

Result: During the six years of monitoring, the incidence of vascular events was 12.4 percent. The dose-response of systolic and diastolic BPV in vascular events, stroke, and coronary heart disease showed an increased risk (quintiles Q2, Q3, and Q4) compared to quintile 1 (Q1). Systolic BPV of ≥12,10 mmHg and diastolic BPV of ≥ 7,31 mmHg had a risk of 2.3 and 1.7 (95% Confidence Intervals (CI)), respectively, for vascular events during the period of 6-year observation, after controlling for age, hypertension status, and lipid profile.

Conclusion: BPV is an independent predictor of vascular events, stroke, and coronary heart disease. The public and clinicians must pay attention to controlling BPV as a risk factor for vascular events, stroke, and CHD.

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来源期刊

Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.