亚洲人JAK抑制剂和种族因素的心血管安全性概况：使用全球ICSR （WHO-UMC VigBase）数据库的信号检测研究

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

International journal of clinical pharmacology and therapeutics Pub Date : 2025-04-01 DOI:10.5414/CP204580

Woongshik Nam, Ji-Hwan Bae, Jeongin Oh, Ju-Young Shin, Hoon Kim

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引用次数: 0

摘要

目的：本研究旨在利用JAK抑制剂的全球个案安全报告数据来检测心血管疾病相关信号。材料和方法：使用WHO-UMC VigiBase进行信号检测研究。结果：本研究确定了亚洲人群中与JAK抑制剂相关的四种心血管不良事件信号，包括肺栓塞、深静脉血栓形成、血栓形成和脑血管意外。结论：对亚洲人群的分析显示，与JAK抑制剂相关的血栓栓塞事件风险高于TNF抑制剂。然而，与西方人群不同的是，在亚洲人群中没有检测到心肌梗死信号。

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Cardiovascular safety profile of JAK inhibitors and ethnic factors in Asians: A signal detection study using the Global ICSR (WHO-UMC VigBase) database.

Objective: This study aimed to detect cardiovascular disease-related signals using Global Individual Case Safety Report data on JAK inhibitors.

Materials and methods: A signal detection study was conducted using the WHO-UMC VigiBase.

Results: This study identified four cardiovascular adverse event signals associated with JAK inhibitors in Asian populations, including pulmonary embolism, deep vein thrombosis, thrombosis, and cerebrovascular accidents.

Conclusion: Analysis of Asian populations revealed a higher risk of thromboembolic events associated with JAK inhibitors than with TNF inhibitors. However, unlike in the Western populations, no myocardial infarction signal was detected in the Asian populations.

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来源期刊

International journal of clinical pharmacology and therapeutics 医学-药学

CiteScore

1.70

自引率

12.50%

发文量

116

审稿时长

4-8 weeks

期刊介绍： The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.