纤维肌痛的过敏性合并症。

IF 2.6 3区 医学 Q2 ALLERGY
Eli Magen, Eugene Merzon, Ilan Green, Israel Magen, Avivit Golan-Cohen, Shlomo Vinker, Ariel Israel
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引用次数: 0

摘要

背景:纤维肌痛(FM)和过敏性疾病之间的关系仍然知之甚少,尽管新出现的证据表明可能存在关联。目的:本研究旨在评估FM患者过敏性合并症的患病率,并与匹配的对照组进行比较。方法:我们在Leumit健康服务中心进行了一项回顾性的、基于人群的病例对照研究,该研究覆盖了约75万名成员。从2002年1月到2023年12月,符合美国风湿病学会不断发展的标准的患者被纳入。对照受试者从相同的人群基础中选择,但没有诊断为FM,在性别,年龄和首次加入的年份上按5:1匹配。所有诊断均采用截至2024年3月的《国际疾病分类第九次修订版》(ICD-9)代码进行鉴定。结果:分析包括15869名确诊为FM的患者和79345名匹配的对照组。两组均以女性占主导地位(82.1%)。与对照组相比,FM患者的支气管哮喘患病率更高,优势比(OR)为1.91。FM患者的非季节性变应性鼻炎和季节性变应性鼻炎的发生率也更高,OR分别为1.60和1.30,无鼻息肉的慢性鼻窦炎的OR为2.46。急性变应性结膜炎OR为2.05。皮肤相关过敏如接触性皮炎和特应性皮炎的or分别为1.48和1.41。此外,FM患者表现出各种形式的荨麻疹和慢性瘙痒的发生率升高,同时食物过敏和特定药物过敏的发生率也较高。食物过敏反应在FM患者中更为常见,其OR为2.50。结论:与对照组相比,FM与较高的过敏性疾病患病率相关。对这些发现的分析表明,在FM管理中需要进行过敏学评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Allergic comorbidities in fibromyalgia.

Background: The relationship between fibromyalgia (FM) and allergic diseases remains poorly understood, despite emerging evidence that suggests a possible association. Objective: This study aimed to evaluate the prevalence of allergic comorbidities in patients with FM compared with a matched control group. Methods: We conducted a retrospective, population-based case-control study within Leumit Health Services, which caters to ∼750,000 members. Patients meeting the evolving criteria of the American College of Rheumatology from January 2002 to December 2023 were included. Control subjects were selected from the same population base but did not have a diagnosis of FM, were matched 5:1 on sex, age, and year of first membership. All diagnoses were identified by using International Classification of Diseases, Ninth Revision (ICD-9) codes up to March 2024. Results: The analysis included 15,869 patients diagnosed with FM and 79,345 matched controls. There was a predominant female representation (82.1%) in both groups. The prevalence of bronchial asthma was higher in patients with FM compared with the controls, with an odds ratio (OR) of 1.91. The patients with FM also exhibited higher rates of both nonseasonal and seasonal allergic rhinitis, with ORs of 1.60 and 1.30, respectively, and chronic rhinosinusitis without nasal polyps demonstrated an OR of 2.46. Acute allergic conjunctivitis had an OR of 2.05. Skin-related allergies such as contact dermatitis and atopic dermatitis showed ORs of 1.48 and 1.41, respectively. Furthermore, the patients with FM displayed elevated rates of various forms of urticaria and chronic pruritus, alongside higher incidences of food allergies and specific drug allergies. Anaphylactic reactions to food were notably more common in patients with FM, who presented an OR of 2.50. Conclusion: FM is associated with a higher prevalence of allergic diseases compared with the controls. Analysis of these findings suggests the need for allergological assessments in FM management.

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来源期刊
CiteScore
5.70
自引率
35.70%
发文量
106
审稿时长
6-12 weeks
期刊介绍: Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
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