从诊断到脱敏的直接超敏反应对口服和肠外铁盐。

IF 2.6 3区 医学 Q2 ALLERGY
Ayse Feyza Aslan, Semra Demir, Ilkim Deniz Toprak, Pelin Korkmaz, Deniz Eyice Karabacak, Nevzat Kahveci, Derya Unal, Asli Gelincik
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引用次数: 0

摘要

背景:铁制剂的超敏反应(HRs)随着铁制剂使用的增加而增加。目的:我们的目的是评估临床特点和我们以前的脱敏方案患者对铁药物的直接超敏反应(IHR)。方法:对96例有口服或静脉注射铁剂ihr病史的患者进行病历筛选。我们评估临床特征和诊断测试结果。此外,我们评估了脱敏方案的安全性和成功率。结果:47例患者有口服铁制剂ihr史,49例患者有静脉注射铁制剂ihr史。52.1%的患者进行了疑似或替代口服铁盐的皮肤点刺试验(SPT),其中5例阳性。分别对67.7%和65.6%的患者进行了spt和IV铁制品皮内试验,其中4例呈阳性。结论:我们的研究表明,皮肤试验对铁制剂的ihr诊断没有帮助,而肠外给药途径与更严重的ihr有关。此外,在必要的情况下,我们的静脉脱敏方案产生的铁羧基麦糖是一种安全,有效,实用的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts.

Background: Hypersensitivity reactions (HRs) to iron agents are increasing in parallel with increased use of iron preparations. Objective: We aimed to evaluate the clinical features and our previous desensitization protocol in patients with immediate hypersensitivity reactions (IHR) to iron agents. Methods: We screened the medical records of 96 patients with a history of IHRs to oral or intravenous (IV) iron agents. We evaluated clinical features and diagnostic test results. Furthermore, we assessed the safety and success rate of the desensitization protocol. Results: Forty-seven patients had a history of IHRs to oral iron preparations, whereas 49 patients had a history of IHRs to IV iron agents. Skin-prick tests (SPT) with suspected and alternative oral iron salts were performed in 52.1% of the patients, and five were positive. SPTs and intradermal tests with IV iron products were applied to 67.7% and 65.6% of the patients, respectively, and four yielded positivity. Anaphylaxis was more common in patients hypersensitive to IV iron agents (n = 33) (p < 0.001). In 15 patients for whom iron agents were mandatory, 52 successful desensitizations with ferric carboxymaltose were performed. Conclusion: Our study demonstrated that skin tests were not helpful in the diagnosis of IHRs to iron agents and the parenteral route of administration was related to more severe IHRs. Furthermore, in case of necessity, our IV desensitization protocol generated for ferric carboxymaltose is a safe, effective, and practical treatment of choice.

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来源期刊
CiteScore
5.70
自引率
35.70%
发文量
106
审稿时长
6-12 weeks
期刊介绍: Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
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