过敏性疾病与高血压的关系:共现模式分析

IF 2.6 3区 医学 Q2 ALLERGY
Xueshan Cao, Guanqi Zhao, Huiyuan Peng, Yuanqi Mi, Mengge Zhou, Yang Guo
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引用次数: 0

摘要

背景:过敏性疾病合并高血压的风险在很大程度上仍然未知。目的:探讨变态反应性疾病共发病模式与高血压发病率和死亡率的关系,并评价变态反应性疾病之间的加性相互作用。方法:纳入2012年美国全国健康访谈调查中具有全国代表性的人群。测定高血压和5种特定变态反应性疾病,包括哮喘、变应性鼻炎(AR)、食物过敏(FA)、湿疹和其他变态反应(OA)。截至2019年12月31日,高血压死亡率已确定。我们评估了两种过敏性疾病对高血压风险的加性相互作用效应:计算了相互作用的相对过量风险(rei)和相互作用联合效应的可归因比例(AP)(以百分比表示)。对于亚组中具有显著异质性的可改变的生活方式因素,我们检查了影响的改变。结果:共纳入34,392名受试者。两种过敏性疾病的四种共发生模式与高血压风险增加相关,包括AR + FA(比值比[OR] 2.25[95%可信区间{CI}, 1.52-3.35])、湿疹+ OA(比值比[OR] 1.94 [95% CI, 1.14-3.30])、AR +湿疹(比值比[OR] 1.76 [95% CI, 1.18-2.64])、哮喘+ AR(比值比[OR] 1.67 [95% CI, 1.33-2.08])。三种过敏性疾病的五种共现模式与高血压风险增加有关。AR + FA存在加性相互作用(RERI, 0.65;AP, 29%),湿疹+ OA (rei, 0.43;AP, 22%), AR +湿疹(rei, 0.21;AP, 12%),哮喘+ AR (RERI, 0.05;美联社,3%)。哮喘+ FA和高血压之间的显著关联仅在体重指数(BMI)≥30 kg/m²的参与者中发现(p = 0.021)。中位随访时间为7.5年,哮喘+ FA共发生的一种模式显示高血压死亡风险显著增加(危险比4.32,95% CI: 1.52-12.23),并观察到加性相互作用(RERI, 2.33;美联社,52%)。结论:我们确定了几种过敏性疾病与高血压发病率和死亡率显著增加的共同发生模式。发现变应性疾病中潜在的生物加性效应及BMI的效应改变。对并发过敏性疾病的患者进行高血压的精准一级预防是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between allergic diseases and hypertension: Co-occurrence pattern analysis.

Background: The hypertension risk in the co-occurrence of allergic diseases remains largely unknown. Objective: We aimed to investigate the association between allergic diseases co-occurrence pattern and hypertension morbidity and mortality, and to evaluate additive interaction effects between allergic diseases. Methods: A nationally representative population from the U.S. National Health Interview Survey 2012 was enrolled. Hypertension and five specific allergic diseases, including asthma, allergic rhinitis (AR), food allergy (FA), eczema, and other allergy (OA), were determined. Hypertension mortality was identified until December 31, 2019. We evaluated additive interaction effects between two allergic diseases on hypertension risk: relative excess risk due to interaction (RERI) and attributable proportion of joint effect due to interaction (AP) (shown as percentages) were calculated. For modifiable lifestyle factors with significant heterogeneity in the subgroups, we examined the effect modification. Results: Totally, 34,392 participants were enrolled. Four co-occurrence patterns of two allergic diseases were associated with an increased risk of hypertension, including AR + FA (odds ratio [OR] 2.25 [95% confidence interval {CI}, 1.52-3.35]), eczema + OA (OR 1.94 [95% CI, 1.14-3.30]), AR + eczema (OR 1.76 [95% CI, 1.18-2.64]), asthma + AR (OR 1.67 [95% CI, 1.33-2.08]). Five co-occurrence patterns of three allergic diseases were associated with increased risk of hypertension. Additive interactions were seen in AR + FA (RERI, 0.65; AP, 29%), eczema + OA (RERI, 0.43; AP, 22%), AR + eczema (RERI, 0.21; AP, 12%), and asthma + AR (RERI, 0.05; AP, 3%). The significant association between asthma + FA and hypertension was only seen among participants with a body mass index (BMI) ≥ 30 kg/m² (p = 0.021). With a median follow-up of 7.5 years, one co-occurrence pattern of asthma + FA showed a significant increased risk of hypertension mortality (hazard ratio 4.32, 95% CI: 1.52-12.23), with an additive interaction was observed (RERI, 2.33; AP, 52%). Conclusion: We identified several allergic diseases co-occurrence patterns with a significantly increased risk of hypertension morbidity and mortality. Potential biologic additive effect among allergic diseases and effect modification of BMI was found. Precision primary prevention of hypertension is necessary for patients with co-occurring allergic diseases.

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来源期刊
CiteScore
5.70
自引率
35.70%
发文量
106
审稿时长
6-12 weeks
期刊介绍: Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
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