含金刚烷和单萜的脲类和咪唑烷-2,4,5-三酮衍生物的合成及镇痛活性研究

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI:10.1134/S1070363224612808

P. E. Rogozin, E. V. Suslov, A. Yu. Filippova, A. V. Pavlova, K. P. Volcho, N. F. Salakhutdinov

引用次数: 0

摘要

合成了一系列含有单萜烯和金刚烷片段的脲和取代对羟基苯甲酸。发现含有(-)-薄荷酮残留的尿素和含有(+)-樟脑醛部分的咪唑烷-2,4,5-三酮衍生物具有镇痛活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Analgesic Activity of Ureas and Imidazolidine-2,4,5-trione Derivatives Containing Adamantane and Monoterpene Fragments

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Synthesis and Analgesic Activity of Ureas and Imidazolidine-2,4,5-trione Derivatives Containing Adamantane and Monoterpene Fragments

A series of ureas and substituted parabanic acids containing monoterpene and adamantane fragments were synthesized. It was found that urea containing a (–)-menthone residue, as well as an imidazolidine-2,4,5-trione derivative with a (+)-campholenaldehyde moiety, exhibit analgesic activity.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.