老年晚期肺癌化疗患者癌症恶病质与心理社会影响的相关性

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing Pub Date : 2025-01-23 DOI:10.1016/j.apjon.2025.100658

Rika Sato , Tateaki Naito , Haruyasu Murakami , Shota Omori , Haruki Kobayashi , Akira Ono , Nobuaki Mamesaya , Kazushige Wakuda , Ryo Ko , Hirotsugu Kenmotsu , Sakiko Aso , Miho Hasaba , Keita Mori , Toshiaki Takahashi , Naoko Hayashi

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引用次数: 0

摘要

目的本研究旨在评估新诊断晚期肺癌接受化疗的老年患者癌症恶病质与心理社会影响、营养影响症状（NIS）和老年评估的关系。方法纳入计划于2021年8月至2022年2月接受一线化疗的晚期肺癌患者。根据国际共识诊断恶病质。使用欧洲癌症研究和治疗组织生活质量问卷（EORTC QLQ） C30、CAX24和饮食相关困扰问卷（ERD）评估NIS和心理社会影响。非参数测试评估恶病质及其影响之间的关系。同意接受采访的恶病质患者被问及他们在饮食和体重变化方面的经历。三位作者对访谈数据进行了审查，以确保分析的准确性。结果31例患者中有21例（68%）基线时患有恶病质。恶病质组的食物厌恶（P = 0.035）、饮食和减肥担忧(P <；与非恶病质组相比，失去控制（P = 0.005）。在ERD和老年评估方面没有显著差异(所有P >；0.05)。访谈显示，患有恶病质的患者很早就意识到饮食和体重的变化，并试图自己控制症状。结论癌症恶病质与NIS和心理社会影响相关。计划接受一线化疗的老年晚期肺癌患者应接受癌症恶病质的综合评估，包括其潜在的生理和心理影响。试验注册试验注册号为UMIN 000053843。

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Correlation between cancer cachexia and psychosocial impact in older patients with advanced lung cancer undergoing chemotherapy

Objective

This study aimed to evaluate the association of cancer cachexia with psychosocial impact, nutrition impact symptoms (NIS), and geriatric assessment in older patients newly diagnosed with advanced lung cancer undergoing chemotherapy.

Methods

Older patients with advanced lung cancer scheduled to receive first-line chemotherapy between August 2021 and February 2022 were enrolled. Cachexia was diagnosed according to the International Consensus. NIS and psychosocial impacts were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ) C30, CAX24, and the Eating-Related Distress Questionnaire (ERD). Non-parametric tests evaluated the association between cachexia and its impacts. Patients with cachexia who consented to be interviewed were asked about their experiences with diet and weight changes. Three authors reviewed the interview data to ensure the analysis's veracity.

Results

Twenty-one of the 31 participants (68%) had cachexia at baseline. The cachexia group showed significantly greater severity of Food Aversion (P = 0.035), Eating and Weight Loss Worry (P < 0.001), and Loss of Control (P = 0.005) compared to the non-cachexia group. There were no significant differences in the ERD and geriatric assessment (all P > 0.05). The interview revealed that patients with cachexia perceived diet and weight changes early on and tried to manage their symptoms by themselves.

Conclusions

Cancer cachexia showed an association with NIS and psychosocial impacts. Older patients with advanced lung cancer scheduled to receive first-line chemotherapy should undergo a comprehensive assessment of cancer cachexia, including its potential physical and psychological impacts.