使用畸变校正OCT定量测绘儿童后眼曲率：颞区形态学的见解

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2025-01-03 DOI:10.1016/j.xops.2024.100695

Takahiro Hiraoka MD, PhD , Masato Tamura MS , Yoshikiyo Moriguchi PhD , Riku Kuji MS , Toshihiro Mino PhD , Masahiro Akiba PhD , Yosuke Takahashi OD , Kenichi Yoshino MD, PhD , Yoshimi Sugiura MD, PhD , Toshifumi Mihashi PhD , Tetsuro Oshika MD, PhD

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引用次数: 0

摘要

目的应用畸变校正广角OCT探讨学龄儿童后眼曲率分布及其与生物特征变量的关系。设计横断面观察性研究。ParticipantsEighty-eight孩子。方法采用重复频率为400 kHz的扫描源-OCT原型系统，采集视场为68 × 68度的大视场视网膜OCT图像。使用每只眼睛单独获得的眼部光学信息，校正获得的OCT图像的畸变。眼后曲率由Bruch膜分割得到的高斯曲率表示。考虑眼轴长（AL）、屈光不正、年龄和脉络膜厚度（ChT），以中央凹为中心的4个区域评估平均高斯曲率。此外，我们确定了进入脉络膜的纤毛后长动脉（LPCA）的入口位置。主要观察指标：后眼局部曲率分布。结果共检查176只眼，其中7只眼因图像质量较差而被排除。对169张OCT图像进行分析，发现双侧脉络膜血管形态和眼后曲度对称。在上、黄斑和下区域，平均曲率与AL、屈光不正和ChT之间存在显著相关性。然而，颞区表现出相反的相关趋势。局部最大曲率点通常在颞区观察到，可能与LPCA进入部位有关。结论sour研究提供了儿童眼后曲率的定量分析，突出了颞区局部最大曲率点。有趣的是，颞区的平均曲率和生物特征变量之间的关系与其他3个区域的关系相矛盾。需要进一步的研究来阐明其起源及其对眼部发育的影响。财务披露专有或商业披露可在本文末尾的脚注和披露中找到。

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Quantitative Mapping of Posterior Eye Curvature in Children Using Distortion-Corrected OCT: Insights into Temporal Region Morphology

Purpose

To explore the curvature distribution in the posterior eye among school-aged children using distortion-corrected widefield OCT and its relationship with biometric variables.

Design

Cross-sectional, observational study.

Participants

Eighty-eight children.

Methods

A swept-source-OCT prototype system with a repetition rate of 400 kHz was used to capture widefield retinal OCT images with a field-of-view of 68 × 68 degrees. The acquired OCT images were corrected for distortion using ocular optical information obtained separately for each eye. The posterior eye curvature was represented by the Gaussian curvature which was derived from Bruch’s membrane segmentation. The mean Gaussian curvature was assessed across 4 regions set centered on the fovea, considering axial length (AL), refractive error, age, and choroidal thickness (ChT). Additionally, we identified the entry site of the long posterior ciliary artery (LPCA) into the choroid.

Main Outcome Measures

Local curvature distribution in the posterior eye.

Results

A total of 176 eyes were imaged, with 7 excluded due to low image quality. Analysis of 169 OCT images revealed bilateral symmetry in choroidal vascular patterns and posterior eye curvature. Significant correlations were noted between mean curvature and AL, refractive error, and ChT in the superior, macular, and inferior regions. However, the temporal region exhibited reversed correlation trends. A local maximum curvature point was commonly observed in the temporal region, potentially linked to the LPCA entry site.

Conclusions

Our study provided a quantitative analysis of posterior eye curvature in children, highlighting a local maximum curvature point in the temporal region. Interestingly, the relationships between mean curvature and biometric variables in the temporal region contradicted those in the other 3 regions. Further investigation is necessary to elucidate its origin and implications for ocular development.