使用[18F] FDG PET/TC进行持续深呼吸评估肺结节

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular Pub Date : 2025-03-01 DOI:10.1016/j.remn.2024.500074

M.S. Casallas Cepeda, S. Salcedo Cortes, I. Gómez Fernández, J. Orcajo Rincón, L. Reguera Berenguer, E.J. Ardila Manjarrez, J.J. Ardila Mantilla, V. Castillo Morales, J. Guzman Cruz, D. Zamudio Rodriguez, A. Marí Hualde, J.E. Montalvá Pastor, S. Álvarez Lara, J.C. Alonso Farto

{"title":"使用[18F] FDG PET/TC进行持续深呼吸评估肺结节","authors":"M.S. Casallas Cepeda, S. Salcedo Cortes, I. Gómez Fernández, J. Orcajo Rincón, L. Reguera Berenguer, E.J. Ardila Manjarrez, J.J. Ardila Mantilla, V. Castillo Morales, J. Guzman Cruz, D. Zamudio Rodriguez, A. Marí Hualde, J.E. Montalvá Pastor, S. Álvarez Lara, J.C. Alonso Farto","doi":"10.1016/j.remn.2024.500074","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>The characterization of pulmonary nodules (PN) is a primary indication for [<sup>18</sup>F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.</div></div><div><h3>Objective</h3><div>Our objective was to compare the diagnostic efficacy of [<sup>18</sup>F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.</div></div><div><h3>Methods</h3><div>We prospectively analyzed 51 patients to assess PN using [<sup>18</sup>F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10mm were analyzed, with pathological anatomy or medical treatment decisions by a multidisciplinary tumor board used as reference.</div></div><div><h3>Results</h3><div>A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values (<em>P</em><.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [18F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.</div></div><div><h3>Conclusions</h3><div>The acquisition of [<sup>18</sup>F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 2","pages":"Article 500074"},"PeriodicalIF":1.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Valoración de los nódulos pulmonares mediante [18F]-FDG PET/TC en inspiración profunda mantenida\",\"authors\":\"M.S. Casallas Cepeda, S. Salcedo Cortes, I. Gómez Fernández, J. Orcajo Rincón, L. Reguera Berenguer, E.J. Ardila Manjarrez, J.J. Ardila Mantilla, V. Castillo Morales, J. Guzman Cruz, D. Zamudio Rodriguez, A. Marí Hualde, J.E. Montalvá Pastor, S. Álvarez Lara, J.C. Alonso Farto\",\"doi\":\"10.1016/j.remn.2024.500074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>The characterization of pulmonary nodules (PN) is a primary indication for [<sup>18</sup>F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.</div></div><div><h3>Objective</h3><div>Our objective was to compare the diagnostic efficacy of [<sup>18</sup>F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.</div></div><div><h3>Methods</h3><div>We prospectively analyzed 51 patients to assess PN using [<sup>18</sup>F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10mm were analyzed, with pathological anatomy or medical treatment decisions by a multidisciplinary tumor board used as reference.</div></div><div><h3>Results</h3><div>A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values (<em>P</em><.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [18F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.</div></div><div><h3>Conclusions</h3><div>The acquisition of [<sup>18</sup>F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.</div></div>\",\"PeriodicalId\":48986,\"journal\":{\"name\":\"Revista Espanola De Medicina Nuclear E Imagen Molecular\",\"volume\":\"44 2\",\"pages\":\"Article 500074\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Espanola De Medicina Nuclear E Imagen Molecular\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2253654X24001070\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Espanola De Medicina Nuclear E Imagen Molecular","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2253654X24001070","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

摘要

肺结节（PN）的特征是[18F]-FDG PET/CT的主要指征。然而，呼吸运动阻碍了这种表征，特别是对于位于下叶的PN。已经开发了各种方法来提高图像分辨率。目的比较[18F]-FDG PET/CT在深度吸气屏气（DIBH）和软件校正自由呼吸评估PN中的诊断效果。方法前瞻性分析51例DIBH患者，采用[18F]-FDG PET/CT评估PN，并采用软件校正自由呼吸。共分析84例平均大小为10mm的结节，并参考多学科肿瘤委员会的病理解剖或药物治疗决定。结果共评估84例PN，比较DIBH组与自由呼吸组，SUVmax值差异有统计学意义（P< 0.05）（自由呼吸组平均SUVmax 3.7， DIBH组平均SUVmax 5.33）。当按叶的位置进行分析时，我们没有发现统计学上的显著差异，尽管在较低的叶中有较高的SUVmax值的趋势。[18F]-FDG PET/CT在DIBH中显示出高灵敏度（95%）和阴性预测值（NPV）（92%），表明它可能是一种很有前途的PN表征工具。结论[18F]-FDG PET/CT对DIBH诊断PN的敏感性和诊断效能均有显著提高。虽然没有发现基于位置的统计学显著差异，但对下叶有潜在的益处。这些发现可以支持其在临床实践中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Valoración de los nódulos pulmonares mediante [18F]-FDG PET/TC en inspiración profunda mantenida

Introduction

The characterization of pulmonary nodules (PN) is a primary indication for [¹⁸F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.

Objective

Our objective was to compare the diagnostic efficacy of [¹⁸F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.

Methods

We prospectively analyzed 51 patients to assess PN using [¹⁸F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10 mm were analyzed, with pathological anatomy or medical treatment decisions by a multidisciplinary tumor board used as reference.

Results

A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values (P<.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [18F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.

Conclusions

The acquisition of [¹⁸F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Revista Espanola De Medicina Nuclear E Imagen Molecular RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.10

自引率

16.70%

发文量

审稿时长

24 days

期刊介绍： The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles.