结核病合并慢性肾脏疾病的流行病学和管理挑战

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-01-01 DOI:10.1016/j.ijtb.2025.02.001

Shubham Chandra , Thomas Vadakkan Devassy

{"title":"结核病合并慢性肾脏疾病的流行病学和管理挑战","authors":"Shubham Chandra , Thomas Vadakkan Devassy","doi":"10.1016/j.ijtb.2025.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Patients with chronic kidney disease (CKD) are more vulnerable to tuberculosis (TB) because of weakened immune systems, which is a serious health risk, especially in low-to-middle-income nations.Epidemiology: CKD patients have a 6.9 to 52.5 times higher risk of developing TB, with dialysis patients at even greater risk.</div></div><div><h3>Pathogenesis</h3><div>Impaired cell-mediated immunity, malnutrition, Vitamin-D deficiency, and Zinc deficiency contribute to TB susceptibility in CKD patients.</div></div><div><h3>Diagnostic challenges</h3><div>Atypical symptoms, nonspecific presentation, and limited diagnostic tools hinder TB diagnosis in CKD patients.</div></div><div><h3>Management</h3><div>Collaborative care and tailored treatment are essential. Anti-TB therapy requires dosing adjustments, careful monitoring, and consideration of comorbid conditions.</div></div><div><h3>Conclusion</h3><div>TB in CKD patients presents a complex clinical picture, requiring heightened awareness and multidisciplinary collaboration. Further research is needed to develop CKD-specific TB screening tools, optimal treatment regimens, and improved understanding of TB-CKD pathophysiology.</div></div>","PeriodicalId":39346,"journal":{"name":"Indian Journal of Tuberculosis","volume":"72 ","pages":"Pages S64-S67"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiological, and management challenges in tuberculosis with chronic kidney disease\",\"authors\":\"Shubham Chandra , Thomas Vadakkan Devassy\",\"doi\":\"10.1016/j.ijtb.2025.02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Patients with chronic kidney disease (CKD) are more vulnerable to tuberculosis (TB) because of weakened immune systems, which is a serious health risk, especially in low-to-middle-income nations.Epidemiology: CKD patients have a 6.9 to 52.5 times higher risk of developing TB, with dialysis patients at even greater risk.</div></div><div><h3>Pathogenesis</h3><div>Impaired cell-mediated immunity, malnutrition, Vitamin-D deficiency, and Zinc deficiency contribute to TB susceptibility in CKD patients.</div></div><div><h3>Diagnostic challenges</h3><div>Atypical symptoms, nonspecific presentation, and limited diagnostic tools hinder TB diagnosis in CKD patients.</div></div><div><h3>Management</h3><div>Collaborative care and tailored treatment are essential. Anti-TB therapy requires dosing adjustments, careful monitoring, and consideration of comorbid conditions.</div></div><div><h3>Conclusion</h3><div>TB in CKD patients presents a complex clinical picture, requiring heightened awareness and multidisciplinary collaboration. Further research is needed to develop CKD-specific TB screening tools, optimal treatment regimens, and improved understanding of TB-CKD pathophysiology.</div></div>\",\"PeriodicalId\":39346,\"journal\":{\"name\":\"Indian Journal of Tuberculosis\",\"volume\":\"72 \",\"pages\":\"Pages S64-S67\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Tuberculosis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0019570725000332\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Tuberculosis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0019570725000332","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

慢性肾脏疾病（CKD）患者更容易感染结核病（TB），因为免疫系统较弱，这是一个严重的健康风险，特别是在低收入和中等收入国家。流行病学：慢性肾病患者患结核病的风险是慢性肾病患者的6.9 - 52.5倍，透析患者的风险更高。细胞介导的免疫功能受损、营养不良、维生素d缺乏和锌缺乏是CKD患者结核病易感性的因素。诊断挑战非典型症状、非特异性表现和有限的诊断工具阻碍了CKD患者的结核病诊断。管理协作护理和量身定制的治疗是必不可少的。抗结核治疗需要调整剂量、仔细监测和考虑合并症。结论CKD患者结核临床表现复杂，需要提高认识，加强多学科合作。需要进一步研究开发ckd特异性结核病筛查工具，最佳治疗方案，并提高对TB- ckd病理生理的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Epidemiological, and management challenges in tuberculosis with chronic kidney disease

Background

Patients with chronic kidney disease (CKD) are more vulnerable to tuberculosis (TB) because of weakened immune systems, which is a serious health risk, especially in low-to-middle-income nations.Epidemiology: CKD patients have a 6.9 to 52.5 times higher risk of developing TB, with dialysis patients at even greater risk.

Pathogenesis

Impaired cell-mediated immunity, malnutrition, Vitamin-D deficiency, and Zinc deficiency contribute to TB susceptibility in CKD patients.

Diagnostic challenges

Atypical symptoms, nonspecific presentation, and limited diagnostic tools hinder TB diagnosis in CKD patients.

Management

Collaborative care and tailored treatment are essential. Anti-TB therapy requires dosing adjustments, careful monitoring, and consideration of comorbid conditions.

Conclusion

TB in CKD patients presents a complex clinical picture, requiring heightened awareness and multidisciplinary collaboration. Further research is needed to develop CKD-specific TB screening tools, optimal treatment regimens, and improved understanding of TB-CKD pathophysiology.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline