继发于肺结核的嗜血球性淋巴组织细胞增多症（HLH）：一个病例系列

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-01-01 DOI:10.1016/j.ijtb.2024.08.020

Chitra Veluthat , Kavitha Venkatnarayan, Uma Maheswari, Uma Devaraj, Priya Ramachandran

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引用次数: 0

摘要

噬血细胞性淋巴组织细胞增多症（HLH）是继发于感染、炎症或恶性肿瘤的一种夸张但无效的免疫反应。HLH的特点是巨噬细胞和t细胞活化，分别导致红细胞、淋巴细胞和血小板的吞噬，以及旺盛的细胞因子反应，导致灾难性的全身表现。HLH的临床和生化特征与败血症有明显的重叠，这可能导致误诊。结核病（TB）是HLH的一个重要传染原因，据报道死亡率超过50%。由于网状内皮系统广泛参与弥散性结核和HLH，因此结核病患者可能误诊HLH。我们提出了一系列的四例结核- hlh入院呼吸重症监护室在三级护理医院。

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Hemophagocytic lymphohistiocytosis (HLH) secondary to tuberculosis: A case series

Hemophagocytic lymphohistiocytosis (HLH) is an exaggerated but ineffective immune response secondary to infections, inflammatory conditions, or malignancies. HLH is characterized by macrophage and T-cell activation resulting in phagocytosis of erythrocytes, lymphocytes, and platelets and an exuberant cytokine response respectively leading to catastrophic systemic manifestations. The clinical and biochemical profile of HLH significantly overlaps with that of sepsis, which may lead to misdiagnosis. Tuberculosis (TB) is an important infectious cause of HLH with a reported mortality of more than 50%. HLH may be misdiagnosed in patients with tuberculosis as the reticuloendothelial system is extensively involved in both disseminated TB and HLH. We present a series of four cases of TB-HLH admitted to the respiratory intensive care unit in a tertiary care hospital.

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline