结核病合并糖尿病患者一线抗结核与抗糖尿病药物的药代动力学相互作用

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-01-01 DOI:10.1016/j.ijtb.2024.10.009

Mary Rebecca Yowaraj , Sudha Vilvamani , T. Bharathiraja , A. Vijayakumar , Kannan Thiruvengadam , Pradeep Menon , Geetha Ramachandran , C. Ponnuraja , Muthu Vijayalakshmi , J. Lavanya , N. Sruthi , A.K. Hemanth Kumar

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引用次数: 0

摘要

几十年来，结核病（TB）和糖尿病（DM）之间的关系一直是一个令人感兴趣的领域。许多研究报道了糖尿病对结核病的发展和预后的影响，反之亦然。在抗结核药物与抗糖尿病药物的药物相互作用方面存在较大的研究空白。因此，本研究对TB合并DM患者一线抗TB与抗糖尿病药物的药物相互作用进行了研究。方法于2018年5月至2020年2月对TB、DM和DMTB三组成人患者进行前瞻性研究。采用高效液相色谱法测定血浆中RMP、INH、PZA、MET、GLB、GLP和GLM的浓度。结果共纳入21例TB、76例DMTB和51例DM患者，分为DM和DMTB亚组。观察到接受一线抗结核药物治疗的DMTB患者血浆中抗糖尿病药物水平发生改变。然而，抗结核药物的水平在糖尿病存在时没有改变，并且无论糖尿病状态如何，检测到亚治疗性利福平浓度。结论本研究为研究抗糖尿病药物相互作用对抗结核药物的影响提供了思路。我们的研究是第一个探索这个谜题的研究。

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查看原文本刊更多论文

Pharmacokinetic drug-drug interaction between first-line anti-TB and anti-diabetic drugs in patients with tuberculosis and diabetes mellitus

Background

The association between Tuberculosis (TB) and Diabetes Mellitus (DM) have always been an area of interest for decades. Many studies have reported the impact of DM on the development and prognosis of TB and vice versa. There is a major research gap in the area of drug-drug interactions between anti-TB drugs and anti-diabetic drugs. Hence, this study investigated the drug-drug interactions between first-line anti-TB and anti-diabetic drugs in patients with TB and DM.

Methodology

A prospective study was undertaken in three groups of adult patients, namely, TB, DM and DMTB from May 2018 to February 2020. Plasma concentrations of RMP, INH, PZA, MET, GLB, GLP and GLM were estimated by high-performance liquid chromatography (HPLC).

Result

21 TB, 76 DMTB and 51 DM patients with subgroups in both DM and DMTB were recruited. It was observed that plasma levels of anti-diabetic drugs were altered in DMTB patients receiving first-line anti-TB drugs. However, the levels of anti-TB drugs were not altered in the presence of DM and irrespective of the DM status, sub-therapeutic rifampicin concentration was detected.

Conclusion

This study provided the roadmap to study the impact of anti-diabetic drug interactions on anti-TB drugs and vice versa. Our study is the first of its kind to explore this puzzle.

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline