从原子核到癌症治疗：BNCT的奇迹，一个核物理学家的观点。成绩与突出问题

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-02-18 DOI:10.1016/j.apradiso.2025.111725

Andrés J. Kreiner

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引用次数: 0

摘要

从核物理学到大多数自然科学和精确科学，强调了BNCT努力的跨学科特征。利用加速质子、α和Li光束进行的放射生物学研究，被用来分离“纯”高LET辐射的相对生物学有效性。根据生存曲线结果，我们讨论了使用固定RBE因子将物理剂量转换为等效或等有效伽马剂量的问题。此外，将物理剂量转换为等效或等有效伽马剂量的必要性也受到质疑。讨论了肿瘤控制概率，并将其作为优化光束整形组件的工具。提到了硼的微分布研究，并指出由于三维的异质性，缺乏一种足够完整的方法来覆盖整个肿瘤。讨论了专为BNCT量身定制的提示伽马单光子发射计算机断层扫描（PG-SPECT）系统的发展，强调它们是实时确定患者宏观平均硼剂量的有力方法。综述了氘核诱导中子产生的研究，重点介绍了BNCT静电四极杆技术的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From the atomic nucleus to cancer cure: The marvel of BNCT a nuclear physicist views. Achievements and outstanding problems

The interdisciplinary character of the BNCT endeavour is stressed ranging from nuclear physics to most of the natural and exact sciences.

Radiobiology studies, carried out with accelerated proton, alpha and Li beams, are used to isolate the relative biological effectiveness of “pure” high LET radiation. Based on the survival curve results, we discuss the question of the use of fixed RBE factors to convert physical doses into equivalent or isoeffective gamma doses. Furthermore, the necessity of converting physical doses into equivalent or isoeffective gamma doses is questioned. Tumor Control Probabilities are discussed and used as a tool to optimize Beam Shaping Assemblies.

Boron microdistribution studies are mentioned and the lack of a sufficiently complete method to cover the whole tumor, given the heterogeneity in 3D, is pointed out.

The development of Prompt Gamma Single Photon Emission Computed Tomography, PG-SPECT, systems especially tailored for BNCT are discussed stressing them as a powerful way of determining in real time the macroscopic average boron dose delivered to the patient.

Studies of deuteron-induced neutron-producing are reviewed and the development of electrostatic quadrupole technology for BNCT is highlighted.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.