不同治疗方法对风湿病患者结核感染的影响

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-02-13 DOI:10.1016/j.jiph.2025.102703

Tianhui Liu , Hongxuan Yan , Mengqiu Gao

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引用次数: 0

摘要

目的探讨风湿病合并结核（TB）患者的临床特点，探讨不同治疗方式下风湿病患者的临床特点。方法收集2009年1月至2022年10月我院风湿病合并结核病患者的临床资料。根据药物治疗将患者分为三组：生物减病抗风湿药物（bDMARDs）组、无免疫治疗组和常规合成减病抗风湿药物（csDMARDs）组。对这三组进行回顾性分析。结果我们发现，使用bDMARDs的患者发生蛀牙的可能性低于其他两组，但更容易发生肺外结核（EPTB）。此外，大多数患者从开始服用bdmard到诊断出结核病的时间间隔为6个月或更短。风湿病患者结核感染的临床特点因治疗方法不同而不同。风湿病患者在不同的治疗方案下表现出不同的临床特征，如结核感染的表现和严重程度的差异。

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Tuberculosis infection in patients with rheumatic diseases under different treatments

Objective

To describe the clinical characteristics of the patients with rheumatic disease who develop tuberculosis(TB), this study investigated the clinical characteristics of patients with rheumatic diseases under different treatments.

Method

We collected clinical data of patients diagnosed with rheumatic diseases complicated with TB at our hospital from January 2009 to October 2022. The patients were divided into three groups based on medication treatments: the biologic Disease Modifying anti-rheumatic drugs（bDMARDs） group, the no-immunotherapy group, and the conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) group. A retrospective analysis was conducted on these three groups.

Results

We found that patients using bDMARDs were less likely to develop cavities than the other two groups but were more likely to have extrapulmonary tuberculosis(EPTB). Additionally, the majority of patients experienced a time interval of 6 months or less from starting bDMARDs to the diagnosis of TB. The clinical characteristics of TB infection in patients with rheumatic diseases vary under different treatments.

Discussion

Patients with rheumatic diseases exhibit distinct clinical characteristics under various treatment regimens, such as differences in the presentation and severity of TB infection.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.