2020-2023年中国人腺病毒感染流行病学特征

IF 3 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Chongyang Li , Yitong Lin , Naiying Mao , Yixuan Gao , Ying Liu , Liwei Sun , Hui Zhang , Jin Xu , Maozhong Li , Feng Zhang , Xiaoqing Liu , Linqing Zhao , Bing Zhu , Ye Chen , Min Mu , Xiaoling Tian , Hongmei Xu , Chaoyang Huang , Zhong Li , Jing Xu , Zhen Zhu
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引用次数: 0

摘要

为了更好地了解2019冠状病毒病(COVID-19)大流行期间和之后中国人腺病毒(hav)感染的流行病学特征,在2020-2023年期间,对14个哨点监测省份的17562例急性呼吸道感染(ARIs)患者进行了呼吸道标本采集。采用市售核酸检测试剂盒对8种常见呼吸道病毒进行检测。对hadv阳性病例的检出率、地理分布、季节分布、人口统计学特征和合并感染状况进行统计分析。本研究结果显示,2020 - 2023年hav总检出率为5.09%(894/ 17562),年检出率从2020年的6.66%逐渐下降至2022年的3.89%,2023年出现反弹(5.19%)。南部地区hav总检出率(6.15%)显著高于北部地区(4.76%)(P <;0.001)。hav感染患者的中位年龄为3岁,其中0-2岁婴幼儿占多数(41.39%)。全年均发现hav阳性病例,没有明显的季节性模式,2020-2023年中国hav流行可能主要由南部地区的病毒感染驱动。合并感染在hadv阳性病例中较为常见(总感染率36.01%),以双重感染为主(79.28%),以人鼻病毒和人呼吸道合胞病毒为最常见的合并感染病原体。综上所述,本研究提示2020-2023年中国hav检出率存在显著的区域和时间差异,应开展持续监测以阐明hav感染的流行病学动态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiological characteristics of human adenovirus infections in China, 2020–2023
To better understand the epidemiological characteristics of human adenovirus (HAdV) infections in China during and after the coronavirus disease 2019 (COVID-19) pandemic, respiratory specimens were collected from 17,562 enrolled patients with acute respiratory infections (ARIs) in 14 sentinel surveillance provinces during 2020–2023. Eight common respiratory viruses were detected using commercially available nucleic acid detection kits. HAdV-positive cases were statistically analyzed for detection rates, geographic distribution, seasonal patterns, demographic characteristics, and co-infection status. The results of this study showed that the overall HAdV detection rate was 5.09 % (894/17,562) during 2020–2023, with a gradual decrease in the annual detection rate from 6.66 % in 2020 to 3.89 % in 2022 and a rebound in 2023 (5.19 %). The overall HAdV detection rate was significantly higher in the southern region (6.15 %) than in the northern region (4.76 %) (P < 0.001). The median age of patients with HAdV infection was 3 years, with infants aged 0–2 years accounting for the majority (41.39 %). HAdV-positive cases were detected throughout the year, with no clear seasonal pattern, and the HAdV epidemic in China during 2020–2023 may have been driven primarily by the virus infection in the southern region. Co-infections were frequent in HAdV-positive cases (overall rate: 36.01 %), primarily consisting of dual infections (79.28 %), with human rhinovirus and human respiratory syncytial virus being the most common coinfecting pathogens. In conclusion, this study suggested the significant regional and temporal variation in HAdV detection rate in China during 2020–2023, and thus ongoing surveillance should be conducted to elucidate the epidemiological dynamics of HAdV infections.
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
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