三种新的延胡索生物碱及其抗增殖活性

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-02-22 DOI:10.1016/j.tetlet.2025.155513

Mei-Shan Li , Li Luo , Gang Wei , Xi-Xi Song , Hai-Ying Luo , Heng-Shan Wang , Jia-Zi Luo

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引用次数: 0

摘要

从紫连珠中分离得到3个未描述的原小檗碱类生物碱，命名为紫连珠碱L-N，以及4个已知化合物。利用核磁共振（NMR）和质谱（MS）对其结构进行了准确表征。通过计算电子圆二色性（ECD）确定了绝对构型。化合物1 ~ 3为较少见的8,13-二羰基原小檗碱类生物碱，在连叶菊属植物中并不常见。所有化合物对四种人类癌细胞系的细胞毒性进行了评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Three new alkaloids from Corydalis saxicola and their antiproliferative activity

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Three new alkaloids from Corydalis saxicola and their antiproliferative activity

Three undescribed protoberberine alkaloids, named corydalisine L-N, along with four known compounds, were isolated from Corydalis saxicola. Their structures were accurately characterized using nuclear magnetic resonance (NMR) and mass spectrometry (MS). The absolute configurations were determined through the calculation of electronic circular dichroism (ECD). Compounds 1–3 were relatively rare 8,13-dicarbonyl protoberbine alkaloids, which are uncommon in plants of the genus Corydalis. All compounds were evaluated for their cytotoxicity against four human cancer cell lines.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.