{"title":"PAR6-aPKC-LGL结构揭示了LGL如何拮抗aPKC","authors":"Daniel St Johnston","doi":"10.1038/s41594-025-01506-8","DOIUrl":null,"url":null,"abstract":"The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL proteins. Until now, it has been unclear how LGL can be both a substrate and inhibitor of aPKC. Now, a cryo-electron microscopy (cryo-EM) structure of a stalled PAR6–aPKC–LGL complex addresses this conundrum.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC\",\"authors\":\"Daniel St Johnston\",\"doi\":\"10.1038/s41594-025-01506-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL proteins. Until now, it has been unclear how LGL can be both a substrate and inhibitor of aPKC. Now, a cryo-electron microscopy (cryo-EM) structure of a stalled PAR6–aPKC–LGL complex addresses this conundrum.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01506-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01506-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC
The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL proteins. Until now, it has been unclear how LGL can be both a substrate and inhibitor of aPKC. Now, a cryo-electron microscopy (cryo-EM) structure of a stalled PAR6–aPKC–LGL complex addresses this conundrum.
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