癌症治疗加速衰老

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2025-02-27 DOI:10.1038/s41568-025-00801-2

Marco Demaria

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引用次数: 0

摘要

癌症治疗的进步导致世界范围内癌症幸存者的人数不断增加，他们经常经历过早发病的年龄相关疾病。了解癌症治疗长期后果的分子和细胞基础对于制定干预措施以减轻其不良影响至关重要。虽然癌症治疗对患者的生存至关重要，但它们往往会导致幸存者出现与过早衰老相关的疾病。在本评论中，Demaria概述了了解这一潜在的分子机制对于制定综合战略以改善幸存者的长期健康结果至关重要。

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Cancer treatments accelerate ageing

Advancements in cancer treatment have led to a growing population of cancer survivors worldwide, who often experience premature onset of age-related conditions. Understanding the molecular and cellular basis of the long-term consequences of cancer treatment is essential for developing interventions to mitigate their adverse effects. While cancer treatments are essential for patient survival, they often induce premature ageing-related conditions in survivors. In this Comment, Demaria outlines how understanding the underlying molecular mechanisms of this is crucial for developing integrated strategies to improve long-term health outcomes in survivors.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.