免疫检查点抑制剂治疗后的抗 PIT1 下丘脑炎

IF 31 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature Reviews Endocrinology Pub Date : 2025-02-27 DOI:10.1038/s41574-025-01099-8

Shin Urai, Genzo Iguchi, Yutaka Takahashi

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摘要

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Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment

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Anti-PIT1 hypophysitis after immune checkpoint inhibitor treatment

Anti-PIT1 hypophysitis is a form of paraneoplastic autoimmune hypophysitis. The condition is attributable to the ectopic expression of pituitary-specific positive transcription factor 1 (PIT1) in tumour tissues, which leads to autoimmunity against PIT1-positive anterior pituitary cells. In the past few years, it has been reported that anti-PIT1 hypophysitis can occur as an immune checkpoint inhibitor-related hypophysitis.

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来源期刊

Nature Reviews Endocrinology 医学-内分泌学与代谢

CiteScore

42.00

自引率

0.70%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.