IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES
Frontiers in Integrative Neuroscience Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI:10.3389/fnint.2025.1500636
Matteo Gambaretti, Luca Viganò, Matteo Gallo, Giovanni Pratelli, Tommaso Sciortino, Lorenzo Gay, Marco Conti Nibali, Alberto Luigi Gallotti, Leonardo Tariciotti, Luca Mattioli, Lorenzo Bello, Gabriella Cerri, Marco Rossi
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引用次数: 0

摘要

自 20 世纪初神经生理学家的重要研究以来,对非人灵长类动物大脑功能的研究为了解神经功能的神经机制提供了宝贵的见解。以在非人灵长类动物身上获得的数据为参考,人类大脑及其功能方面的知识取得了重大进展。必须认识到这一科学努力所带来的转化影响,特别是在支持神经外科方法治疗脑肿瘤的现有外科技术的实施方面。在脑肿瘤的外科治疗中,最大限度地扩大切除范围可以提高患者的总生存率、无进展生存率和生活质量。肿瘤神经外科手术的主要目标,同时也是主要挑战,是在达到最大切除范围的同时避免永久性神经功能缺损,尤其是当肿瘤浸润到维持运动功能的神经网络时。人们利用神经电生理探针开发了脑图绘制技术,以确定支持感觉运动功能的区域和神经束,确保在切除过程中保留这些区域和神经束。在过去的 20 年中,从经典的 "Penfield "技术开始,脑图绘制技术逐步得到应用。其中最主要的进步是引入了高频直接电刺激技术。该技术的完善以及低频刺激的补充使用,使得刺激方案得以进一步完善。在这篇叙述性综述中,我们将分析从非人灵长类实验中获得的知识是如何影响和改变当前神经外科手术方法的。然后,我们将介绍用于切除位于感觉运动回路中的肿瘤的主要脑图绘制技术。我们还详细介绍了这些技术如何获取有关感觉运动控制基础区域和神经束特性的新数据,进而设计出新的工具,用于在皮层和皮层下区域内进行导航,而这些区域以前被认为是 "神圣不可触碰 "的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From non-human to human primates: a translational approach to enhancing resection, safety, and indications in glioma surgery while preserving sensorimotor abilities.

Since the pivotal studies of neurophysiologists in the early 20th century, research on brain functions in non-human primates has provided valuable insights into the neural mechanisms subserving neurological function. By using data acquired on non-human primates as a reference, important progress in knowledge of the human brain and its functions has been achieved. The translational impact allowed by this scientific effort must be recognized in the implementation of the current surgical techniques particularly in support of the neurosurgical approach to brain tumors. In the surgical treatment of brain tumors, the ability to maximally extend the resection allows an improvement in overall survival, progression-free survival, and quality of life of patients. The main goal, and, at the same time, the main challenge, of oncological neurological surgery is to avoid permanent neurological deficit while reaching maximal resection, particularly when the tumor infiltrates the neural network subserving motor functions. Brain mapping techniques were developed using neurophysiological probes to identify the areas and tracts subserving sensorimotor function, ensuring their preservation during the resection. During the last 20 years, starting from the classical "Penfield" technique, brain mapping has been progressively implemented. Among the major advancements was the introduction of high-frequency direct electrical stimulation. Its refinement, along with the complementary use of low-frequency stimulation, allowed a further refinement of stimulation protocols. In this narrative review, we propose an analysis of the process through which the knowledge acquired through experiments on non-human primates influenced and changed the current approach to neurosurgical procedures. We then describe the main brain mapping techniques used in the resection of tumors located within sensorimotor circuits. We also detail how these techniques allowed the acquisition of new data on the properties of areas and tracts underlying sensorimotor control, in turn fostering the design of new tools to navigate within cortical and subcortical areas, that were before deemed to be "sacred and untouchable."

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来源期刊
Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience
CiteScore
4.60
自引率
2.90%
发文量
148
审稿时长
14 weeks
期刊介绍: Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.
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