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IF 3.6 3区生物学 Q1 BIOLOGY

Biology-Basel Pub Date : 2025-02-16 DOI:10.3390/biology14020209

Enes Karaman, Fatih Yay, Durmus Ayan, Ergul Bayram, Sefa Erturk

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引用次数: 0

摘要

背景：Sparc/osteonectin、cwcv和kazal样结构域蛋白多糖1（SPOCK1）是一种癌基因，在某些类型的癌症中会促进肿瘤的形成和发展，并与不良生存率有关。然而，有关 SPOCK1 在妇科癌症中的重要性的文献资料十分有限。本研究旨在探讨 SPOCK1 在卵巢浆液性囊腺癌（OV）、宫颈鳞状细胞癌和宫颈内膜腺癌（CESC）以及子宫体子宫内膜癌（UCEC）中的作用。研究方法本研究使用的数据来自 GEPIA2、TCGA、Kaplan-Meier Plotter、GeneMANIA、UALCAN、cBioPortal 和 TIMER 数据库。总生存率（OS）和无复发生存率（RFS）通过 Kaplan-Meier 生存分析进行评估。SPOCK1的表达与不同免疫细胞的肿瘤浸润之间的相关性获得了斯皮尔曼rho值和统计学意义值。结果显示与正常组织相比，CESC和UCEC中的SPOCK1基因表达量较低（P < 0.05），但OV中的SPOCK1基因表达量差异不大（P > 0.05）。在OV中，SPOCK1基因表达只与年龄有关；在CESC中，它与年龄、分期、体重和组织学有关；在UCEC中，它与年龄、分期、体重和绝经状态有关。结论：SPOCK1基因在UCEC中的表达与CD8+ T细胞呈弱正相关，与CD4+ T细胞呈弱负相关。SPOCK1可能是妇科癌症的潜在预后和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Clinopathological and Prognostic Significance of SPOCK1 in Gynecological Cancers: A Bioinformatics Based Analysis.

Background: Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) is an oncogene that promotes tumor formation and progression in certain types of cancer and is associated with poor survival rates. However, there is limited information on the importance of SPOCK1 in gynecological cancers in the literature. The aim of this study was to explore the role of SPOCK1 in ovarian serous cystadenocarcinoma (OV), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), and uterine corpus endometrial carcinomas (UCEC). Methods: The data used in this study were obtained from the GEPIA2, TCGA, Kaplan-Meier Plotter, GeneMANIA, UALCAN, cBioPortal, and TIMER databases. Overall survival (OS) and relapse-free survival (RFS) rates were evaluated by Kaplan-Meier survival analysis. Spearman's rho and statistical significance values were obtained for the correlation between SPOCK1 expression and tumor infiltration by different immune cells. Results: Lower SPOCK1 gene expression was observed in CESC and UCEC compared to normal tissue (p < 0.05), but the OV did not differ significantly (p > 0.05). In OV, SPOCK1 gene expression was solely linked to age; in CESC, it was linked to age, stage, weight, and histology; and in UCEC, it was linked to age, stage, weight, and menopausal status. Conclusions:SPOCK1 gene expression in UCEC showed weak positive correlations with CD8+ T cells and weak negative correlations with CD4+ T cells. SPOCK1 may be a potential prognostic and therapeutic target for gynecological cancers.

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来源期刊

Biology-Basel Biological Science-Biological Science

CiteScore

5.70

自引率

4.80%

发文量

1618

审稿时长

11 weeks

期刊介绍： Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.