在《赫尔辛基宣言》的60年里追寻“脆弱性”。

IF 1.6 Q2 ETHICS
Monash Bioethics Review Pub Date : 2025-06-01 Epub Date: 2025-02-25 DOI:10.1007/s40592-025-00235-4
Oskar Lindholm, Sakari Karjalainen, Veikko Launis
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引用次数: 0

摘要

2024年是世界医学协会《赫尔辛基宣言》发表60周年。巧合的是,世界医学会发布了这一具有里程碑意义的文件的第8版,该文件指导涉及人类受试者的医学研究。这个最新版本的一个关键变化涉及脆弱性的概念,这一直是DoH精神的核心。“脆弱”一词在2000年出版的第五版中明确引入,其中列出了五个脆弱群体。随后的修订大大改变了如何在文档中描述和理解漏洞。本文在DoH的不同版本中追溯了漏洞的概念,并在其最近发布的第8版中达到高潮。我们将探讨每次修订的基本原则,并研究这些原则如何影响和被更广泛的伦理话语影响。最后,我们解决了未来修订必须满足的一些挑战,以确保该文件保持内部连贯,并实际适用于研究人员和研究伦理委员会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chasing 'vulnerability' across six decades of the Declaration of Helsinki.

The year 2024 marked the 60th anniversary of the World Medical Association's Declaration of Helsinki (DoH). Coincidentally, the WMA published the 8th revision of this landmark document guiding medical research involving human subjects. One of the key changes in this latest revision concerns the notion of vulnerability, which has always been central to the DoH's ethos. The term 'vulnerability' was explicitly introduced in the 5th revision, published in 2000, which lists five vulnerable groups. Subsequent revisions have significantly altered how vulnerability is portrayed and understood within the document. This article traces the conceptualisation of vulnerability across the various versions of the DoH, culminating in its recently published 8th revision. We explore the underlying principles of each revision and examine how these principles have both influenced and been influenced by broader ethical discourses. Lastly, we address some of the challenges that future revisions must meet to ensure that the document remains internally coherent and practically applicable for researchers and research ethics committees alike.

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来源期刊
CiteScore
2.70
自引率
6.20%
发文量
16
期刊介绍: Monash Bioethics Review provides comprehensive coverage of traditional topics and emerging issues in bioethics. The Journal is especially concerned with empirically-informed philosophical bioethical analysis with policy relevance. Monash Bioethics Review also regularly publishes empirical studies providing explicit ethical analysis and/or with significant ethical or policy implications. Produced by the Monash University Centre for Human Bioethics since 1981 (originally as Bioethics News), Monash Bioethics Review is the oldest peer reviewed bioethics journal based in Australia–and one of the oldest bioethics journals in the world. An international forum for empirically-informed philosophical bioethical analysis with policy relevance. Includes empirical studies providing explicit ethical analysis and/or with significant ethical or policy implications. One of the oldest bioethics journals, produced by a world-leading bioethics centre. Publishes papers up to 13,000 words in length. Unique New Feature: All Articles Open for Commentary
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