Tuning the value of sweet food: Blocking sweet taste receptors increases the devaluation effect in a go/no-go task.

Despite the apparent simplicity of the go/no-go (GNG) task, in which individuals selectively respond or withhold responses, there is strong evidence supporting its efficacy in terms of modulating food preferences. Herein, we manipulated sweet taste perception and investigated the no-go devaluation effect that is typically observed due to GNG training with respect to sweet and savory food items. Prior to engaging in a GNG task, one group of participants rinsed their mouths with a liquid solution containing gymnemic acid, thereby transiently and selectively inhibiting sweet taste perception, while another group used a placebo solution. The participants who rinsed their mouths with gymnemic acid exhibited a stronger overall decrease in food evaluations from pre to post training. Furthermore, a pronounced no-go devaluation effect was observed for sweet foods, irrespective of the rinsing solution. Overall, our results support the notion that training in the GNG task can induce changes in the valuation of food stimuli, particularly for sweet foods.