伴有同步肝转移的胰腺神经内分泌肿瘤手术治疗的远期疗效：一项多中心回顾性队列研究。

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI:10.1097/MPA.0000000000002417

Qiang Xu, Bohui Yin, Xu Han, Siqian Ren, Jialin Jiang, Fang Li, Karn Wijarnpreecha, Jingqiao Wang, Quan Liao, Menghua Dai, Taiping Zhang, Abuduhaibaier Sadula, Wenhui Lou, Chunhui Yuan, Wenming Wu, Yupei Zhao

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引用次数: 0

摘要

目的：探讨手术对胰腺神经内分泌肿瘤（pNEN）伴同步肝转移（sHMs）患者总生存期（OS）的影响。方法：从国内3家机构招募163例pen - shm患者，将患者分为未切除组、原发灶切除组、原发灶及肝灶同时切除组（PHR）。采用Cox回归评估手术对OS的影响。结果：在整体队列分析中，PHR对OS具有显著的保护作用(风险比为0.302；95%置信区间为0.127-0.721；P = 0.007)。然而，亚组分析显示，PHR在胰腺体/尾胰腺神经内分泌肿瘤（pNET）（bp -pNET- shm）患者中具有生存优势(风险比，0.287；95% ci, 0.087-0.946；P = 0.040)，而手术治疗对胰腺神经内分泌癌- shm或胰腺头颈部pNET-sHM （hn-pNET-sHM）亚组的生存率没有显著影响。结论：在本研究中，仅在bt-pNET-sHM亚组中观察到手术的生存益处。考虑到决策的多因素性质，pNEN-sHM治疗的手术干预应经过仔细和全面的评估，以防止过度的手术策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Long-term Outcomes of Surgical Treatment for Pancreatic Neuroendocrine Neoplasm With Synchronous Hepatic Metastasis: A Multicenter Retrospective Cohort Study.

Objective: To evaluate surgical impact on the overall survival (OS) of pancreatic neuroendocrine neoplasm (pNEN) with synchronous hepatic metastases (sHMs).

Methods: A total of 163 pNEN-sHM patients were recruited from 3 institutions in China, who were categorized into 3 groups: no resection, resection of the primary lesion, and resection of both primary and hepatic lesions (PHR). Cox regression was employed to evaluate surgical impact on the OS.

Results: In the overall cohort analysis, PHR demonstrated a significant protective effect on OS (hazard ratio, 0.302; 95% confidence interval, 0.127-0.721; P = 0.007). Nevertheless, subgroup analysis revealed PHR conferred a survival advantage in patients with pancreatic neuroendocrine tumor (pNET) located on the pancreatic body/tail (bt-pNET-sHM) (hazard ratio, 0.287; 95% CI, 0.087-0.946; P = 0.040), whereas surgical treatment did not significantly impact survival in the subgroups of pancreatic neuroendocrine carcinoma-sHM or pancreatic head/neck pNET-sHM (hn-pNET-sHM).

Conclusions: In this study, the survival benefit of surgery was observed only in the bt-pNET-sHM subgroup. Considering the multifactorial nature of decision-making, surgical intervention for pNEN-sHM management should be approached with a careful and comprehensive assessment, to prevent excessive surgery strategies.

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.