癌前病变进化中恶性克隆选择的环境驱动因素。

IF 5.9 1区生物学 Q2 CELL BIOLOGY

Cell Proliferation Pub Date : 2025-02-25 DOI:10.1111/cpr.70011

Yancheng Lai, Shaosen Zhang

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引用次数: 0

摘要

体细胞突变积累和随后的恶性克隆选择是导致癌症的过程。其复杂性包括暴露于致癌物以及这些暴露与遗传、多基因或表观遗传易感性相互作用的方式。环境因素是如何影响健康细胞向恶性细胞的初始转化的，以及它们在促进癌变细胞的生长、侵袭、免疫逃逸、炎症和耐药等方面的作用是值得研究的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Environmental Drivers of Malignant Clonal Selection in Precancerous Lesion Evolution

Somatic mutations accumulation and subsequent malignant clonal selection are the processes that lead to cancer. The intricacy includes exposure to carcinogens as well as the ways in which these exposures interact with genetic, polygenic, or epigenetic predispositions. It is worthwhile to investigate how environmental factors influence the initial transformation of healthy cells into malignant ones, or their effects on promoting growth, invasion, immune evasion, inflammation and drug resistance of onset cancerous cells.

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来源期刊

Cell Proliferation 生物-细胞生物学

CiteScore

14.80

自引率

2.40%

发文量

198

审稿时长

1 months

期刊介绍： Cell Proliferation Focus: Devoted to studies into all aspects of cell proliferation and differentiation. Covers normal and abnormal states. Explores control systems and mechanisms at various levels: inter- and intracellular, molecular, and genetic. Investigates modification by and interactions with chemical and physical agents. Includes mathematical modeling and the development of new techniques. Publication Content: Original research papers Invited review articles Book reviews Letters commenting on previously published papers and/or topics of general interest By organizing the information in this manner, readers can quickly grasp the scope, focus, and publication content of Cell Proliferation.