人造玻璃纤维与呼吸系统健康后果流行病学的系统回顾和荟萃分析。

IF 1.8 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Damien M McElvenny, Ireny Iskandar, Sarah Daniels, Matthew Gittins, Martie van Tongeren
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引用次数: 0

摘要

人造玻璃纤维(MMVFs)也被称为人造矿物纤维(MMMFs),是指主要由玻璃、岩石、矿物、矿渣、玻璃和加工过的无机氧化物制成的非晶体、纤维状无机材料。国际癌症研究机构将岩(石)棉、玻璃棉和连续玻璃细丝列为第3类(不按致癌性分类)。本研究包含呼吸健康结果和mmmf的最新系统综述和荟萃分析。方法:检索中国、EMBASE、Medline、Web of Science和OpenGrey等网站,检索职业性MMMF暴露与恶性和非恶性呼吸系统疾病的流行病学研究。采用系统评价和荟萃分析首选报告项目(PRISMA)指南进行报告。对队列研究和病例对照研究分别进行meta分析。结果:共有25项研究被纳入系统评价,其中19项(9个队列;10例病例对照)为meta分析提供风险估计。在队列研究中,3项在瑞典进行,加拿大和美国各2项,法国1项,以及几个欧洲国家1项。后续研究的开始时间为1933年至1975年。队列研究中肺癌的meta-RR(发病率或死亡率)为1.15 (95% CI: 1.01至1.32),喉癌的meta-RR为1.03 (95% CI: 0.78至1.37),非恶性呼吸系统疾病(NMRD)的meta-RR为0.89 (95% CI: 0.66至1.22)。在病例对照研究中,有9项是肺癌研究,1项是喉癌研究。其中三项肺癌研究在法国进行,德国、俄罗斯、加拿大和中国各有一项研究,一项在几个欧洲国家进行,一项是对来自全球的几个病例队列进行的巢式病例对照研究。病例对照研究中肺癌的meta-OR为1.28 (95% CI: 1.10 - 1.50)。结论:我们的研究结果与先前发表的一项呼吸系统癌症荟萃分析基本一致,因为它们在相对风险程度上是相似的。然而,总的来说,我们的研究结果表明,mmmf暴露与肺癌的风险增加有关,但在统计学上具有显著性,而与喉癌或NMRDs无关。考虑到研究之间的异质性和残留混淆的可能性,需要进一步的工作来确定这种关联是否存在因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systematic review and meta-analysis of the epidemiology of man-made vitreous fibres and respiratory health outcomes.

Objectives: The generic term man-made vitreous fibres (MMVFs) also known as man-made mineral fibres (MMMFs) denotes non-crystalline, fibrous inorganic material manufactured primarily from glass, rock, minerals, slag, glass, and processed inorganic oxides. The International Agency for Research on Cancer has classified rock (stone) wool, glass wool, and continuous glass filament as Group 3 (not classifiable for carcinogenicity). This study contains an updated systematic review and meta-analysis of respiratory health outcomes and MMMFs.

Methods: Cinahl, EMBASE, Medline, Web of Science, and OpenGrey were searched for epidemiological studies of occupational MMMF exposure and malignant and non-malignant respiratory diseases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adopted for reporting. Meta-analyses were carried out separately for cohort and case-control studies.

Results: A total of 25 studies were identified for inclusion in the systematic review, with 19 of these (9 cohort; 10 case-control) providing risk estimates for the meta-analyses. Of the cohort studies, 3 were carried out in Sweden, 2 each in Canada and the United States, one in France, and one several European countries. The start of follow-up ranged from 1933 to 1975. The meta-RR for lung cancer from cohort studies (incidence or mortality) was 1.15 (95% CI: 1.01 to 1.32), for laryngeal cancer was 1.03 (95% CI: 0.78 to 1.37), and for non-malignant respiratory diseases (NMRD) mortality was 0.89 (95% CI: 0.66 to 1.22). Of the case-control studies, 9 examined lung cancer and one laryngeal cancer. Three of the lung cancer studies were carried out in France and one each in Germany, Russia, Canada, and China, with one in several European countries and one was a nested case-control study of several case cohorts from across the globe. The meta-OR for lung cancer from the case-control studies was 1.28 (95% CI: 1.10 to 1.50).

Conclusions: Our findings broadly agree with a previously published meta-analysis of respiratory system cancers, in that they were similar in terms of magnitude of relative risk. However, overall, our results suggest that exposure to MMMFs is associated with a small, but statistically significantly elevated risk for lung cancer, but not for laryngeal cancer or NMRDs. Given the heterogeneity between studies, and the possibility of residual confounding, further work is required to determine if this association is causal.

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来源期刊
Annals Of Work Exposures and Health
Annals Of Work Exposures and Health Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.60
自引率
19.20%
发文量
79
期刊介绍: About the Journal Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?" We are interested in high quality scientific research addressing: the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures; the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities; populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers; the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems; policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities; methodologies and mechanisms that underlie the quantification and/or control of exposure and risk. There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.
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