解码神经酰胺功能：定位如何塑造细胞命运以及如何研究它。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-04-01 DOI:10.1016/j.tibs.2025.01.007

Shweta Chitkara , G. Ekin Atilla-Gokcumen

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引用次数: 0

摘要

最近的研究强调，脂质合成、代谢和转运在调节脂质功能中起着至关重要的作用，强调了细胞内脂质定位的重要性，以及它们的化学结构。神经酰胺在这种情况下脱颖而出，因为它们在细胞过程中起着多方面的作用。在这里，我们关注神经酰胺在细胞凋亡、衰老和自噬中的作用，因为这些过程为神经酰胺如何发挥作用以及与亚细胞定位的复杂联系提供了独特而不同的视角，为它们复杂的生物相互作用提供了重要的见解。此外，我们强调了工具和技术的最新进展，这些进展促进了我们对神经酰胺动力学和脂质功能不同机制的理解。

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Decoding ceramide function: how localization shapes cellular fate and how to study it

Recent studies emphasize that lipid synthesis, metabolism, and transport are crucial in modulating lipid function, underscoring the significance of lipid localization within the cell, in addition to their chemical structure. Ceramides stand out in this context because of their multifaceted roles in cellular processes. Here, we focus on the role of ceramides in apoptosis, senescence, and autophagy as these processes offer unique and contrasting perspectives on how ceramides function and can be intricately linked to their subcellular localization, providing critical insights into their complex biological interactions. Additionally, we highlight recent advancements in tools and techniques that have boosted our understanding of ceramide dynamics and different mechanisms of lipid functioning.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.