{"title":"绵羊新鲜组织胸腔镜下先天性食管闭锁及气管食管瘘模型的建立","authors":"Mustafa Azizoglu, Mehmet Hanifi Okur","doi":"10.1002/bdr2.2458","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>This study aimed to develop an esophageal atresia (EA) model using fresh sheep esophagus, trachea, and lungs to simulate a realistic thoracoscopic surgical environment.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A thoracoscopic trainer box was used with fresh sheep tissues (esophagus, trachea, and lungs) to create an EA and tracheoesophageal fistula (TEF) model. The distal esophagus was anastomosed to the trachea, and a bicycle pump was integrated to simulate lung function. Additional components, such as a simulated azygos vein and parietal pleura, enhanced the model's realism for surgical training.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The developed EA-TEF model was created in six steps, including pleural dissection, azygos vein control, TEF division, and esophageal anastomosis. The procedure used a thoracoscopic trainer box, sheep tissues, and standard instruments. A bicycle pump simulated lung function, and careful techniques were employed for vein ligation and esophageal anastomosis. After the posterior wall was sutured, an 8 Fr feeding tube was inserted. The total cost of the model was $260, with reusable equipment and a $10 recurring cost for sheep tissues.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This study successfully developed a cost-effective and anatomically accurate thoracoscopic model for EA and TEF repair using fresh sheep tissue.</p>\n </section>\n </div>","PeriodicalId":9121,"journal":{"name":"Birth Defects Research","volume":"117 3","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of a Thoracoscopic Model for Birth Defect Esophageal Atresia and Tracheoesophageal Fistula Using Fresh Sheep Tissues\",\"authors\":\"Mustafa Azizoglu, Mehmet Hanifi Okur\",\"doi\":\"10.1002/bdr2.2458\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>This study aimed to develop an esophageal atresia (EA) model using fresh sheep esophagus, trachea, and lungs to simulate a realistic thoracoscopic surgical environment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A thoracoscopic trainer box was used with fresh sheep tissues (esophagus, trachea, and lungs) to create an EA and tracheoesophageal fistula (TEF) model. The distal esophagus was anastomosed to the trachea, and a bicycle pump was integrated to simulate lung function. Additional components, such as a simulated azygos vein and parietal pleura, enhanced the model's realism for surgical training.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The developed EA-TEF model was created in six steps, including pleural dissection, azygos vein control, TEF division, and esophageal anastomosis. The procedure used a thoracoscopic trainer box, sheep tissues, and standard instruments. A bicycle pump simulated lung function, and careful techniques were employed for vein ligation and esophageal anastomosis. After the posterior wall was sutured, an 8 Fr feeding tube was inserted. The total cost of the model was $260, with reusable equipment and a $10 recurring cost for sheep tissues.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>This study successfully developed a cost-effective and anatomically accurate thoracoscopic model for EA and TEF repair using fresh sheep tissue.</p>\\n </section>\\n </div>\",\"PeriodicalId\":9121,\"journal\":{\"name\":\"Birth Defects Research\",\"volume\":\"117 3\",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-02-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Birth Defects Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2458\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2458","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Development of a Thoracoscopic Model for Birth Defect Esophageal Atresia and Tracheoesophageal Fistula Using Fresh Sheep Tissues
Background
This study aimed to develop an esophageal atresia (EA) model using fresh sheep esophagus, trachea, and lungs to simulate a realistic thoracoscopic surgical environment.
Methods
A thoracoscopic trainer box was used with fresh sheep tissues (esophagus, trachea, and lungs) to create an EA and tracheoesophageal fistula (TEF) model. The distal esophagus was anastomosed to the trachea, and a bicycle pump was integrated to simulate lung function. Additional components, such as a simulated azygos vein and parietal pleura, enhanced the model's realism for surgical training.
Results
The developed EA-TEF model was created in six steps, including pleural dissection, azygos vein control, TEF division, and esophageal anastomosis. The procedure used a thoracoscopic trainer box, sheep tissues, and standard instruments. A bicycle pump simulated lung function, and careful techniques were employed for vein ligation and esophageal anastomosis. After the posterior wall was sutured, an 8 Fr feeding tube was inserted. The total cost of the model was $260, with reusable equipment and a $10 recurring cost for sheep tissues.
Conclusions
This study successfully developed a cost-effective and anatomically accurate thoracoscopic model for EA and TEF repair using fresh sheep tissue.
期刊介绍：
The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks.
Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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