Ana-Marija Milisav, Lamborghini Sotelo, Cristina Cantallops-Vilà, Tommaso Fontanot, Ina Erceg, Krunoslav Bojanić, Tomislav Vuletić, Željka Fiket, Maja Ivanić, Silke Christiansen, Edwige Meurice, Maja Dutour Sikirić
{"title":"嵌入银和氧化铜纳米粒子的聚氨基酸LbL多层生物相容性抗菌涂层","authors":"Ana-Marija Milisav, Lamborghini Sotelo, Cristina Cantallops-Vilà, Tommaso Fontanot, Ina Erceg, Krunoslav Bojanić, Tomislav Vuletić, Željka Fiket, Maja Ivanić, Silke Christiansen, Edwige Meurice, Maja Dutour Sikirić","doi":"10.1002/admi.202400631","DOIUrl":null,"url":null,"abstract":"<p>The growing concern over implant-associated infections motivates the development of novel antibacterial coatings for medical devices as an effective strategy in reducing the occurrence of IAI. Polyelectrolyte multilayers (PEMs) incorporating metal/metal oxide nanoparticles (NPs) as antimicrobial components receive special attention for their ability to coat diverse surface types and low potential to induce antimicrobial resistance. This study investigates the potential of poly(amino acid) multilayers consisting of poly-L-lysine and poly-L-glutamic acid with embedded silver (PEMAg) or copper oxide (PEMCuO) deposited on titanium surfaces for the coating of medical surfaces. The results of the quartz crystal microbalance with dissipation, scanning electron microscopy, and electron dispersive spectroscopy show that both types of NPs are successfully incorporated in the PEM and deposited over the entire coated surface. The incorporation of NPs in PEM prevents the burst release. The viability of MG-63 cells is higher than 70% on all investigated PEMs, confirming their biocompatibility. PEMCuO shows better biofilm prevention compared to PEMAg, entirely preventing <i>Pseudomonas aeruginosa</i> biofilm and allowing the formation of only weak <i>Staphylococcus aureus</i> biofilm. The results obtained confirm the high potential of poly(amino acids) multilayers with embedded metal/metal oxide NPs as biocompatible antimicrobial coatings for medical devices.</p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"12 5","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202400631","citationCount":"0","resultStr":"{\"title\":\"Poly(Amino Acid) LbL Multilayers With Embedded Silver and Copper Oxide Nanoparticles as Biocompatible Antibacterial Coatings\",\"authors\":\"Ana-Marija Milisav, Lamborghini Sotelo, Cristina Cantallops-Vilà, Tommaso Fontanot, Ina Erceg, Krunoslav Bojanić, Tomislav Vuletić, Željka Fiket, Maja Ivanić, Silke Christiansen, Edwige Meurice, Maja Dutour Sikirić\",\"doi\":\"10.1002/admi.202400631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The growing concern over implant-associated infections motivates the development of novel antibacterial coatings for medical devices as an effective strategy in reducing the occurrence of IAI. 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Poly(Amino Acid) LbL Multilayers With Embedded Silver and Copper Oxide Nanoparticles as Biocompatible Antibacterial Coatings
The growing concern over implant-associated infections motivates the development of novel antibacterial coatings for medical devices as an effective strategy in reducing the occurrence of IAI. Polyelectrolyte multilayers (PEMs) incorporating metal/metal oxide nanoparticles (NPs) as antimicrobial components receive special attention for their ability to coat diverse surface types and low potential to induce antimicrobial resistance. This study investigates the potential of poly(amino acid) multilayers consisting of poly-L-lysine and poly-L-glutamic acid with embedded silver (PEMAg) or copper oxide (PEMCuO) deposited on titanium surfaces for the coating of medical surfaces. The results of the quartz crystal microbalance with dissipation, scanning electron microscopy, and electron dispersive spectroscopy show that both types of NPs are successfully incorporated in the PEM and deposited over the entire coated surface. The incorporation of NPs in PEM prevents the burst release. The viability of MG-63 cells is higher than 70% on all investigated PEMs, confirming their biocompatibility. PEMCuO shows better biofilm prevention compared to PEMAg, entirely preventing Pseudomonas aeruginosa biofilm and allowing the formation of only weak Staphylococcus aureus biofilm. The results obtained confirm the high potential of poly(amino acids) multilayers with embedded metal/metal oxide NPs as biocompatible antimicrobial coatings for medical devices.
期刊介绍:
Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018.
The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface.
Advanced Materials Interfaces covers all topics in interface-related research:
Oil / water separation,
Applications of nanostructured materials,
2D materials and heterostructures,
Surfaces and interfaces in organic electronic devices,
Catalysis and membranes,
Self-assembly and nanopatterned surfaces,
Composite and coating materials,
Biointerfaces for technical and medical applications.
Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.