嵌入银和氧化铜纳米粒子的聚氨基酸LbL多层生物相容性抗菌涂层

IF 4.3 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Ana-Marija Milisav, Lamborghini Sotelo, Cristina Cantallops-Vilà, Tommaso Fontanot, Ina Erceg, Krunoslav Bojanić, Tomislav Vuletić, Željka Fiket, Maja Ivanić, Silke Christiansen, Edwige Meurice, Maja Dutour Sikirić
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引用次数: 0

摘要

对植入物相关感染的日益关注促使医疗器械新型抗菌涂层的发展,作为减少IAI发生的有效策略。含有金属/金属氧化物纳米颗粒(NPs)作为抗菌成分的聚电解质多层膜(PEMs)因其涂覆不同表面类型的能力和诱导抗微生物耐药性的低潜力而受到特别关注。本研究探讨了在钛表面沉积由聚赖氨酸和聚谷氨酸和嵌入银(PEMAg)或氧化铜(PEMCuO)组成的聚氨基酸多层膜用于医疗表面涂层的潜力。石英晶体耗散微天平、扫描电镜和电子色散光谱的结果表明,两种类型的NPs都成功地结合在PEM中,并沉积在整个涂覆表面。在PEM中加入NPs可以防止爆发释放。MG-63细胞的存活率均高于70%,证实了其生物相容性。与PEMAg相比,PEMCuO具有更好的生物膜预防作用,完全阻止铜绿假单胞菌的生物膜形成,只允许形成弱金黄色葡萄球菌的生物膜。结果证实了嵌入金属/金属氧化物NPs的聚氨基酸多层膜作为医疗器械生物相容性抗菌涂层的高潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Poly(Amino Acid) LbL Multilayers With Embedded Silver and Copper Oxide Nanoparticles as Biocompatible Antibacterial Coatings

Poly(Amino Acid) LbL Multilayers With Embedded Silver and Copper Oxide Nanoparticles as Biocompatible Antibacterial Coatings

The growing concern over implant-associated infections motivates the development of novel antibacterial coatings for medical devices as an effective strategy in reducing the occurrence of IAI. Polyelectrolyte multilayers (PEMs) incorporating metal/metal oxide nanoparticles (NPs) as antimicrobial components receive special attention for their ability to coat diverse surface types and low potential to induce antimicrobial resistance. This study investigates the potential of poly(amino acid) multilayers consisting of poly-L-lysine and poly-L-glutamic acid with embedded silver (PEMAg) or copper oxide (PEMCuO) deposited on titanium surfaces for the coating of medical surfaces. The results of the quartz crystal microbalance with dissipation, scanning electron microscopy, and electron dispersive spectroscopy show that both types of NPs are successfully incorporated in the PEM and deposited over the entire coated surface. The incorporation of NPs in PEM prevents the burst release. The viability of MG-63 cells is higher than 70% on all investigated PEMs, confirming their biocompatibility. PEMCuO shows better biofilm prevention compared to PEMAg, entirely preventing Pseudomonas aeruginosa biofilm and allowing the formation of only weak Staphylococcus aureus biofilm. The results obtained confirm the high potential of poly(amino acids) multilayers with embedded metal/metal oxide NPs as biocompatible antimicrobial coatings for medical devices.

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来源期刊
Advanced Materials Interfaces
Advanced Materials Interfaces CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
8.40
自引率
5.60%
发文量
1174
审稿时长
1.3 months
期刊介绍: Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018. The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface. Advanced Materials Interfaces covers all topics in interface-related research: Oil / water separation, Applications of nanostructured materials, 2D materials and heterostructures, Surfaces and interfaces in organic electronic devices, Catalysis and membranes, Self-assembly and nanopatterned surfaces, Composite and coating materials, Biointerfaces for technical and medical applications. Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.
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