放射生物学中闪光效应的分子机制

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2025-02-26 DOI:10.1134/S0006350924700830

S. I. Glukhov, E. A. Kuznetsova

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引用次数: 0

摘要

使用超高剂量率（≥40戈瑞/秒）的电离辐射，即所谓的FLASH辐射，有助于保存健康组织，其肿瘤控制水平与标准剂量率的辐射相当。本文综述了目前在常规和FLASH模式下对肿瘤、正常细胞系和动物（包括肿瘤携带者）的辐照研究中获得的知识。为了比较，还提供了光子、电子、质子以及氦离子和碳离子辐照FLASH的数据。生物物理，分子生物学和免疫学方面的闪光暴露是必要的了解辐射诱导的过程在细胞和组织，以改善肿瘤放疗进行了讨论。

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The Molecular Mechanisms of the FLASH Effect in Radiobiology

The use of ionizing radiation at an ultra-high dose rate (≥40 Gy/s), which is called FLASH irradiation, contributes to the preservation of healthy tissues with a level of tumor control comparable to that of irradiation at a standard dose rate. This review summarizes the current knowledge obtained in studies of irradiation of tumor and normal cell lines and animals, including tumor carriers, in conventional and FLASH modes. For comparison, data on FLASH irradiation with photons, electrons, and protons, as well as ions of helium and carbon, are also provided. The biophysical, molecular biological, and immunological aspects of FLASH exposure necessary for understanding radiation-induced processes in cells and tissues in order to improve tumor radiotherapy are discussed.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.