{"title":"CTCF和黏结蛋白介导染色质斑点基态结合","authors":"","doi":"10.1038/s41594-024-01466-5","DOIUrl":null,"url":null,"abstract":"The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CTCF and cohesin mediate the chromatin–speckle ground-state association\",\"authors\":\"\",\"doi\":\"10.1038/s41594-024-01466-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"29 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-024-01466-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-024-01466-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CTCF and cohesin mediate the chromatin–speckle ground-state association
The association of chromatin with nuclear speckles is crucial in gene regulation. Here, cell biology and genomic methods revealed that the chromatin factors CTCF and cohesin are key organizers of chromatin–speckle interactions. This organization enhanced speckle-proximal gene activation, linking nuclear architecture to gene regulation and developmental disorders.
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