卵巢癌剪接变异研究综述。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-22 DOI:10.1016/j.bbcan.2025.189288

Min Zhou, Mengdie Tian, Zhuoer Li, Chunli Wang, Zhiqiang Guo

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引用次数: 0

摘要

卵巢癌仍然是最致命的妇科恶性肿瘤之一，尽管免疫疗法取得了令人鼓舞的进展，但其死亡率仍然居高不下。异常剪接事件在癌症异质性和耐药性中起着至关重要的作用。许多剪接变异，尤其是涉及 BRCA1/2 等关键分子标记的剪接变异，与疾病进展和治疗效果密切相关。这些变异和相关剪接因子作为诊断和预后生物标志物及治疗靶点具有重要的临床价值。本综述全面概述了卵巢癌中的剪接变异，强调了它们在转移和抗药性中的作用，并为推进生物标记物的开发和治疗策略提供了见解。

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Overview of splicing variation in ovarian cancer

Ovarian cancer remains one of the deadliest gynecological malignancies, with a persistently high mortality rate despite promising advancements in immunotherapy. Aberrant splicing events play a crucial role in cancer heterogeneity and treatment resistance. Many splicing variants, especially those involving key molecular markers such as BRCA1/2, are closely linked to disease progression and treatment outcomes. These variants and related splicing factors hold significant clinical value as diagnostic and prognostic biomarkers and therapeutic targets. This review provides a comprehensive overview of splicing variants in ovarian cancer, emphasizing their role in metastasis and resistance, and offers insights to advance biomarker development and treatment strategies.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.