大麻使用与女性不孕症：2013-2018年全国健康与营养检查调查的横断面分析。

IF 3.3 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Epidemiology Pub Date : 2025-02-22 DOI:10.1016/j.annepidem.2025.02.008

Megha Arora BS , Sarah K. Dzubay BS , Aine Huntington MPH , Kristin C. Prewitt MD, MPH , Sarah B. Andrea PhD, MPH

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引用次数: 0

摘要

目的：尽管大麻使用在美国越来越普遍，但描述大麻使用对生育影响的文献有限。这项研究调查了大麻使用频率与女性不孕症之间的关系。方法：我们使用2013-2018年国家健康与营养检查研究（NHANES）对20-49岁女性进行了大麻使用频率和不孕（一年内无法怀孕）的横断面分析。利用调整社会人口统计学、健康状况和其他物质使用的多变量logistic回归模型来估计调整后的优势比（aOR）、95%置信区间（CI），并根据开始经常使用药物的年龄和婚姻状况评估结果。结果：在纳入的3167名妇女中，12.4%报告不孕。不孕症患病率在不规律使用大麻的人群中为10.6%，在经常使用大麻的人群中为15.4%。与从不使用相比，经常使用的女性不孕的几率增加53% (aOR: 1.53；95% CI: 0.91, 2.55)，不规律使用的妇女不孕的几率降低17% (aOR: 0.83；95% CI: 0.54, 1.27)，无统计学意义。与开始使用的年龄和婚姻状况相关。结论：我们的研究结果表明，经常使用大麻和不孕症之间可能存在适度的联系，这为专业协会的建议和患者咨询提供了越来越多的证据。

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Cannabis use & female infertility: A cross sectional analysis of the National Health and Nutrition Examination Survey, 2013–2018

Purpose

Despite growing prevalence of cannabis use in the U.S., literature describing the impact of cannabis use on fertility is limited. This study investigates the association between frequency of cannabis use and female infertility.

Methods

We conducted a cross-sectional analysis of frequency of cannabis use and infertility (inability to conceive within a year) using the 2013–2018 National Health and Nutrition Examination Study (NHANES) for women aged 20–49. Multivariable logistic regression models adjusting for sociodemographics, health status, and other substance use were utilized to estimate adjusted odds ratios (aOR), 95 % confidence intervals (CI), and assess results by age of regular use initiation and marital status.

Results

Of the 3167 women included, 12.4 % reported infertility. Infertility prevalence was 10.6 % among those with irregular cannabis use and 15.4 % among those with regular use. Compared to never use, women with regular use had 53 % greater odds of infertility (aOR: 1.53; 95 % CI: 0.91, 2.55) and women with irregular use had 17 % lower odds of infertility (aOR: 0.83; 95 % CI: 0.54, 1.27), without statistical significance. Associations were robust to age of initiation of use and marital status.

Conclusions

Our results suggest a possible modest association between regular cannabis use and infertility, adding to a growing body of evidence which can inform professional society recommendations and patient counseling.

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来源期刊

Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

1.80%

发文量

207

审稿时长

59 days

期刊介绍： The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.