环境空气污染与帕金森病和阿尔茨海默病：最新的 Meta 分析。

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2025-02-15 DOI:10.3390/toxics13020139

Cuiyao Xie, Xi Xia, Kai Wang, Jie Yan, Lijun Bai, Liqiong Guo, Xiaoxue Li, Shaowei Wu

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引用次数: 0

摘要

背景：以往的流行病学证据表明，环境空气污染与阿尔茨海默病（AD）和帕金森病（PD）这两种主要的神经退行性疾病之间存在关联，但目前仍无定论：本研究旨在评估长期和短期暴露于 PM2.5 和 PM10（即空气动力直径大于或小于 2.5 μm 或 10 μm 的颗粒物）、二氧化氮（NO2）、臭氧、二氧化硫和一氧化碳与阿尔茨海默病和帕金森病风险之间的关系：方法：在荟萃分析中采用随机效应模型总结个体效应估计值。结果：共纳入了42项符合条件的研究：共纳入了 42 项符合条件的研究。PM2.5长期暴露量每增加5微克/立方米，AD和PD的几率比（ORs）分别为1.16（95% CI：1.04，1.30；I2 = 95%）和1.10（95% CI：1.03，1.17；I2 = 95%）。PM2.5短期暴露量每增加5微克/立方米，PD的OR值为1.01（95% CI：1.002，1.01；I2 = 77%）。二氧化氮长期暴露量每增加 1 ppb，PD 的 OR 值为 1.01（95% CI：1.0002，1.02；I2 = 79%）：结论：环境空气污染，尤其是 PM2.5，可能会导致包括注意力缺失症和注意力缺失症在内的神经退行性疾病的风险增加。

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Ambient Air Pollution and Parkinson's Disease and Alzheimer's Disease: An Updated Meta-Analysis.

Background: Previous epidemiological evidence regarding the associations between ambient air pollution and two major neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD), remains inconclusive.

Objective: This study aimed to evaluate the associations between long-term and short-term exposure to PM_2.5 and PM₁₀ (i.e., particulate matter with an aerodynamic diameter of, or smaller than, 2.5 μm or 10 μm), nitrogen dioxide (NO₂), ozone, sulfur dioxide, and carbon monoxide and the risks of AD and PD.

Methods: A random-effects model was used to summarize individual effect estimates in the meta-analysis. A subgroup meta-analysis was further conducted to explore the potential sources of heterogeneity.

Results: In total, 42 eligible studies were included. For each 5 μg/m³ increase in long-term PM_2.5 exposure, the odds ratios (ORs) were 1.16 (95% CI: 1.04, 1.30; I² = 95%) and 1.10 (95% CI: 1.03, 1.17; I² = 95%) for AD and PD, respectively. For each 5 μg/m³ increase in short-term PM_2.5 exposure, the OR was 1.01 (95% CI: 1.002, 1.01; I² = 77%) for PD. For each 1 ppb increase in long-term NO₂ exposure, the OR was 1.01 (95% CI: 1.0002, 1.02; I² = 79%) for PD.

Conclusion: Ambient air pollution, particularly PM_2.5, may contribute to the increased risks of neurodegenerative diseases including AD and PD.

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.