居住邻近、土地利用特征及呼出挥发性有机物对哮喘儿童肺功能的影响

IF 4.4 Q1 TOXICOLOGY

Journal of Xenobiotics Pub Date : 2025-02-05 DOI:10.3390/jox15010027

Bo-Yu Hsiao, Chun-Sheng Huang, Chang-Fu Wu, Kuo-Liong Chien, Hsiao-Yu Yang

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引用次数: 0

摘要

背景：城市空气污染对儿童呼吸系统有不利影响，但挥发性有机化合物（VOCs）对儿童肺功能的影响尚不清楚。本研究旨在确定哮喘儿童呼出的挥发性有机化合物与土地利用特征和肺功能下降有关，并探索影响挥发性有机化合物暴露水平的环境阈值。方法：选取台湾省彰化县97名年龄在7 ~ 20岁的哮喘患儿，收集其个人及居住资料、呼出VOC样本及肺功能检测。土地使用特征来源于儿童的居住地址。本研究使用两个模型来探讨土地利用、VOC水平和肺功能之间的关系。结果：m/对二甲苯、1,3,5-三甲基苯和1,2,4-三甲基苯是FEV1/FVC的关键因子，显著预测FEV1/FVC < 90% (AUC = 0.66；95% CI: 0.53 ~ 0.79)。这些挥发性有机化合物还与儿童之家周围300米缓冲区内的主要道路区域有关。结论：本研究填补了低水平室外VOC暴露与儿童呼吸健康的研究空白，研究了1,3,5-三甲基苯、1,2,4-三甲基苯和间/对二甲苯作为儿童肺功能受损的潜在生物标志物。

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Residential Proximity Land Use Characteristics and Exhaled Volatile Organic Compounds' Impact on Pulmonary Function in Asthmatic Children.

Background: Urban air pollution adversely affects children's respiratory systems, but the impact of volatile organic compounds (VOCs) on children's pulmonary function remains unclear. This study aims to identify exhaled VOCs linked to land use characteristics and reduced pulmonary function in asthmatic children, as well as to explore environmental thresholds influencing VOC exposure levels.

Methods: We enrolled 97 asthmatic children, aged 7 to 20, from Changhua County, Taiwan, and collected personal and residential data, collected exhaled VOC samples, and conducted pulmonary function tests. Land use characteristics were derived from the children's residential addresses. This study used two models to explore the relationships between land use, VOC levels, and pulmonary function.

Results: Our results show that m/p-xylene, 1,3,5-trimethylbenzene, and 1,2,4-trimethylbenzene were key contributors to FEV₁/FVC and significantly predicted FEV₁/FVC < 90% (AUC = 0.66; 95% CI: 0.53 to 0.79). These VOCs were also linked to major road areas within a 300 m buffer around children's homes.

Conclusions: This study fills a research gap on low-level outdoor VOC exposure and pediatric respiratory health, examining 1,3,5-trimethylbenzene, 1,2,4-trimethylbenzene, and m/p-xylene as potential biomarkers for impaired pulmonary function in children.

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来源期刊

Journal of Xenobiotics TOXICOLOGY-

CiteScore

5.30

自引率

1.70%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics.